ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive therapeutic strategy to treat allergic diseases. Oroso...

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Bibliographic Details
Main Authors: Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Immunology
Subjects:
orosomucoid-like 3
mast cell activation
degranulation
activating transcription factor 6
autophagy
passive cutaneous anaphylaxis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.604974/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.604974/full

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