Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for...

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Main Authors:	Eunyoung Lim, Jeremy Ricci, Mankil Jung
Format:	Article
Language:	English
Published:	MDPI AG 2011-11-01
Series:	Molecules
Subjects:	dimethyl lithospermate B target identification photochemical and fluorescent probe dual probe
Online Access:	http://www.mdpi.com/1420-3049/16/12/9886/

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spelling	doaj-66809372dc954acf8827d69820549ac52020-11-24T21:29:55ZengMDPI AGMolecules1420-30492011-11-0116129886989910.3390/molecules16129886Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent PropertiesEunyoung LimJeremy RicciMankil JungDimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.http://www.mdpi.com/1420-3049/16/12/9886/dimethyl lithospermate Btarget identificationphotochemical and fluorescent probedual probe
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Eunyoung Lim Jeremy Ricci Mankil Jung
spellingShingle	Eunyoung Lim Jeremy Ricci Mankil Jung Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties Molecules dimethyl lithospermate B target identification photochemical and fluorescent probe dual probe
author_facet	Eunyoung Lim Jeremy Ricci Mankil Jung
author_sort	Eunyoung Lim
title	Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_short	Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_full	Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_fullStr	Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_full_unstemmed	Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
title_sort	synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent properties
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2011-11-01
description	Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.
topic	dimethyl lithospermate B target identification photochemical and fluorescent probe dual probe
url	http://www.mdpi.com/1420-3049/16/12/9886/
work_keys_str_mv	AT eunyounglim synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties AT jeremyricci synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties AT mankiljung synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties
_version_	1725964896017842176

Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties

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