Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties
Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for...
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2011-11-01
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doaj-66809372dc954acf8827d69820549ac52020-11-24T21:29:55ZengMDPI AGMolecules1420-30492011-11-0116129886989910.3390/molecules16129886Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent PropertiesEunyoung LimJeremy RicciMankil JungDimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization.http://www.mdpi.com/1420-3049/16/12/9886/dimethyl lithospermate Btarget identificationphotochemical and fluorescent probedual probe |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eunyoung Lim Jeremy Ricci Mankil Jung |
spellingShingle |
Eunyoung Lim Jeremy Ricci Mankil Jung Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties Molecules dimethyl lithospermate B target identification photochemical and fluorescent probe dual probe |
author_facet |
Eunyoung Lim Jeremy Ricci Mankil Jung |
author_sort |
Eunyoung Lim |
title |
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties |
title_short |
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties |
title_full |
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties |
title_fullStr |
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties |
title_full_unstemmed |
Synthesis of a Dual-Labeled Probe of Dimethyl Lithospermate B with Photochemical and Fluorescent Properties |
title_sort |
synthesis of a dual-labeled probe of dimethyl lithospermate b with photochemical and fluorescent properties |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2011-11-01 |
description |
Dimethyl lithosermate B (DLB) is a highly potent natural antioxidant and antidiabetic polyphenol with unknown mode of action. To determine its cellular targets, a photochemical and fluorescent dimethyl lithopermate B probe was designed and efficiently synthesized. The dual-labeled chemical probe for biological application was evaluated by UV and fluorescence to determine its electrochemical absorption and emission properties. This probe could be valuable for investigating ligand-protein interactions and subcellular localization. |
topic |
dimethyl lithospermate B target identification photochemical and fluorescent probe dual probe |
url |
http://www.mdpi.com/1420-3049/16/12/9886/ |
work_keys_str_mv |
AT eunyounglim synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties AT jeremyricci synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties AT mankiljung synthesisofaduallabeledprobeofdimethyllithospermatebwithphotochemicalandfluorescentproperties |
_version_ |
1725964896017842176 |