Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity
Retinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibil...
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doaj-668ca67239c245369401d7eded5f4d772021-06-15T12:13:14ZengKarger PublishersCase Reports in Ophthalmology1663-26992021-04-0112130631010.1159/000513181513181Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of PrematurityRuba Saleh Alghofaili0Saleh A. Almesfer1Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi ArabiaDepartment of Pediatric Ophthalmology, King Khaled Eye Specialist Hospital, Riyadh, Saudi ArabiaRetinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibility that the 2 conditions. Here, we report the sixth such case of co-occurring ROP and RB in an 8-month-old infant conceived by in vitro fertilization (IVF) who developed bilateral retinoblastoma a few months after treatment for advanced-stage ROP. While the ROP was initially adequately managed, bilateral RB necessitated bilateral enucleation. This case raises a number of important questions about whether IVF, ROP, and RB are causally related. Although the associations between IVF, ROP, and RB are likely to be coincidental, this case nevertheless highlights that ROP patients require regular follow-up for early diagnosis and treatment of ocular sequelae including RB.https://www.karger.com/Article/FullText/513181in vitro fertilizationleukocoriaretinopathy of prematurityretinoblastoma |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ruba Saleh Alghofaili Saleh A. Almesfer |
spellingShingle |
Ruba Saleh Alghofaili Saleh A. Almesfer Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity Case Reports in Ophthalmology in vitro fertilization leukocoria retinopathy of prematurity retinoblastoma |
author_facet |
Ruba Saleh Alghofaili Saleh A. Almesfer |
author_sort |
Ruba Saleh Alghofaili |
title |
Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity |
title_short |
Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity |
title_full |
Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity |
title_fullStr |
Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity |
title_full_unstemmed |
Bilateral Retinoblastoma Presenting in an in vitro Fertilization Infant with Retinopathy of Prematurity |
title_sort |
bilateral retinoblastoma presenting in an in vitro fertilization infant with retinopathy of prematurity |
publisher |
Karger Publishers |
series |
Case Reports in Ophthalmology |
issn |
1663-2699 |
publishDate |
2021-04-01 |
description |
Retinopathy of prematurity (ROP) and retinoblastoma (RB) are well-described entities in premature babies. Although their pathogeneses are different, with ROP representing a disorder of interrupted development and RB a genetic disease, a few co-occurring cases have been reported, raising the possibility that the 2 conditions. Here, we report the sixth such case of co-occurring ROP and RB in an 8-month-old infant conceived by in vitro fertilization (IVF) who developed bilateral retinoblastoma a few months after treatment for advanced-stage ROP. While the ROP was initially adequately managed, bilateral RB necessitated bilateral enucleation. This case raises a number of important questions about whether IVF, ROP, and RB are causally related. Although the associations between IVF, ROP, and RB are likely to be coincidental, this case nevertheless highlights that ROP patients require regular follow-up for early diagnosis and treatment of ocular sequelae including RB. |
topic |
in vitro fertilization leukocoria retinopathy of prematurity retinoblastoma |
url |
https://www.karger.com/Article/FullText/513181 |
work_keys_str_mv |
AT rubasalehalghofaili bilateralretinoblastomapresentinginaninvitrofertilizationinfantwithretinopathyofprematurity AT salehaalmesfer bilateralretinoblastomapresentinginaninvitrofertilizationinfantwithretinopathyofprematurity |
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1721376494294401024 |