Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies
This chapter focusses on oncolytic Newcastle disease virus (NDV). It summarizes i) the peculiarities of this virus as an anti-cancer and immune stimulatory agent and ii) approaches to further harness it as a vector to combat cancer. Special emphasis is given on combining virus therapy with cell ther...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2014-09-01
|
Series: | Frontiers in Oncology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00224/full |
id |
doaj-668deaa7cc914123a124577bdc191ce1 |
---|---|
record_format |
Article |
spelling |
doaj-668deaa7cc914123a124577bdc191ce12020-11-25T01:05:54ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2014-09-01410.3389/fonc.2014.00224104690Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodiesVolker eSchirrmacher0Philippe eFournier1Immunologisches Onkologisches Zentrum KölnGerman Cancer Research Institute,This chapter focusses on oncolytic Newcastle disease virus (NDV). It summarizes i) the peculiarities of this virus as an anti-cancer and immune stimulatory agent and ii) approaches to further harness it as a vector to combat cancer. Special emphasis is given on combining virus therapy with cell therapy and on improving tumor targeting. The review will include some of the authors work on NDV, bispecific antibodies and cell therapy as building blocks for a new perspective of multimodal cancer therapy. The broad anti-tumor immune reactivation includes innate and adaptive, tumor antigen specific and tumor antigen independent activities.http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00224/fullDendritic CellsNewcastle disease virusT cellshyperthermiacellular therapytumor targeting |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Volker eSchirrmacher Philippe eFournier |
spellingShingle |
Volker eSchirrmacher Philippe eFournier Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies Frontiers in Oncology Dendritic Cells Newcastle disease virus T cells hyperthermia cellular therapy tumor targeting |
author_facet |
Volker eSchirrmacher Philippe eFournier |
author_sort |
Volker eSchirrmacher |
title |
Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies |
title_short |
Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies |
title_full |
Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies |
title_fullStr |
Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies |
title_full_unstemmed |
Multimodal cancer therapy involving oncolytic Newcastle Disease Virus, autologous immune cells and bispecific antibodies |
title_sort |
multimodal cancer therapy involving oncolytic newcastle disease virus, autologous immune cells and bispecific antibodies |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2014-09-01 |
description |
This chapter focusses on oncolytic Newcastle disease virus (NDV). It summarizes i) the peculiarities of this virus as an anti-cancer and immune stimulatory agent and ii) approaches to further harness it as a vector to combat cancer. Special emphasis is given on combining virus therapy with cell therapy and on improving tumor targeting. The review will include some of the authors work on NDV, bispecific antibodies and cell therapy as building blocks for a new perspective of multimodal cancer therapy. The broad anti-tumor immune reactivation includes innate and adaptive, tumor antigen specific and tumor antigen independent activities. |
topic |
Dendritic Cells Newcastle disease virus T cells hyperthermia cellular therapy tumor targeting |
url |
http://journal.frontiersin.org/Journal/10.3389/fonc.2014.00224/full |
work_keys_str_mv |
AT volkereschirrmacher multimodalcancertherapyinvolvingoncolyticnewcastlediseasevirusautologousimmunecellsandbispecificantibodies AT philippeefournier multimodalcancertherapyinvolvingoncolyticnewcastlediseasevirusautologousimmunecellsandbispecificantibodies |
_version_ |
1725192613549572096 |