Trial watch: IDO inhibitors in cancer therapy
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of the so-called “kynurenine pathway”, which converts the essential amino acid L-tryptophan (Trp) into the immunosuppressive metabolite L-kynurenine (Kyn). While expressed constitutively by some tissues, IDO1 can also be in...
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Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1777625 |
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doaj-669c282eafa44c86b28adc9e9db32fad2021-09-24T14:41:25ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.17776251777625Trial watch: IDO inhibitors in cancer therapyJulie Le Naour0Lorenzo Galluzzi1Laurence Zitvogel2Guido Kroemer3Erika Vacchelli4Université De Paris, Sorbonne Université, INSERM U1138, Centre De Recherche Des CordeliersWeill Cornell Medical CollegeGustave Roussy Cancer CampusUniversité De Paris, Sorbonne Université, INSERM U1138, Centre De Recherche Des CordeliersUniversité De Paris, Sorbonne Université, INSERM U1138, Centre De Recherche Des CordeliersIndoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of the so-called “kynurenine pathway”, which converts the essential amino acid L-tryptophan (Trp) into the immunosuppressive metabolite L-kynurenine (Kyn). While expressed constitutively by some tissues, IDO1 can also be induced in specific subsets of antigen-presenting cells that ultimately favor the establishment of immune tolerance to tumor antigens. At least in part, the immunomodulatory functions of IDO1 can be explained by depletion of Trp and accumulation of Kyn and its derivatives. In animal tumor models, genetic or pharmacological IDO1 inhibition can cause the (re)activation of anticancer immune responses. Similarly, neoplasms expressing high levels of IDO1 may elude anticancer immunosurveillance. Therefore, IDO1 inhibitors represent promising therapeutic candidates for cancer therapy, and some of them have already entered clinical evaluation. Here, we summarize preclinical and clinical studies testing IDO1-targeting interventions for oncologic indications.http://dx.doi.org/10.1080/2162402X.2020.1777625dendritic cellsimmune checkpoint blockersepacadostatindoximodnavoximod |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Le Naour Lorenzo Galluzzi Laurence Zitvogel Guido Kroemer Erika Vacchelli |
spellingShingle |
Julie Le Naour Lorenzo Galluzzi Laurence Zitvogel Guido Kroemer Erika Vacchelli Trial watch: IDO inhibitors in cancer therapy OncoImmunology dendritic cells immune checkpoint blockers epacadostat indoximod navoximod |
author_facet |
Julie Le Naour Lorenzo Galluzzi Laurence Zitvogel Guido Kroemer Erika Vacchelli |
author_sort |
Julie Le Naour |
title |
Trial watch: IDO inhibitors in cancer therapy |
title_short |
Trial watch: IDO inhibitors in cancer therapy |
title_full |
Trial watch: IDO inhibitors in cancer therapy |
title_fullStr |
Trial watch: IDO inhibitors in cancer therapy |
title_full_unstemmed |
Trial watch: IDO inhibitors in cancer therapy |
title_sort |
trial watch: ido inhibitors in cancer therapy |
publisher |
Taylor & Francis Group |
series |
OncoImmunology |
issn |
2162-402X |
publishDate |
2020-01-01 |
description |
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first, rate-limiting step of the so-called “kynurenine pathway”, which converts the essential amino acid L-tryptophan (Trp) into the immunosuppressive metabolite L-kynurenine (Kyn). While expressed constitutively by some tissues, IDO1 can also be induced in specific subsets of antigen-presenting cells that ultimately favor the establishment of immune tolerance to tumor antigens. At least in part, the immunomodulatory functions of IDO1 can be explained by depletion of Trp and accumulation of Kyn and its derivatives. In animal tumor models, genetic or pharmacological IDO1 inhibition can cause the (re)activation of anticancer immune responses. Similarly, neoplasms expressing high levels of IDO1 may elude anticancer immunosurveillance. Therefore, IDO1 inhibitors represent promising therapeutic candidates for cancer therapy, and some of them have already entered clinical evaluation. Here, we summarize preclinical and clinical studies testing IDO1-targeting interventions for oncologic indications. |
topic |
dendritic cells immune checkpoint blockers epacadostat indoximod navoximod |
url |
http://dx.doi.org/10.1080/2162402X.2020.1777625 |
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1717369751914676224 |