Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways
A high consumption of vegetables belonging to the Brassicaceae family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glu...
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doaj-66af5b0289304e88baa45763d02d1bfc2020-11-24T22:08:53ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-09-01189189010.3390/ijms18091890ijms18091890Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling PathwaysChristine Sturm0Anika E. Wagner1Institute of Nutritional Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, GermanyInstitute of Nutritional Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, GermanyA high consumption of vegetables belonging to the Brassicaceae family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glucosinolates (GLSs)—secondary plant compounds nearly exclusively present in Brassicaceae—and in particular to their bioactive breakdown products including isothiocyanates (ITCs). Overall, the current literature indicate that selected Brassica-derived ITCs exhibit health-promoting effects in vitro, as well as in laboratory mice in vivo. Some studies suggest anti-carcinogenic and anti-inflammatory properties for ITCs which may be communicated through an activation of the redox-sensitive transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) that controls the expression of antioxidant and phase II enzymes. Furthermore, it has been shown that ITCs are able to significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo. As there are studies available suggesting an epigenetic mode of action for Brassica-derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern.https://www.mdpi.com/1422-0067/18/9/1890BrassicaceaeisothiocyanatessulforaphaneNrf2NFκBepigenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christine Sturm Anika E. Wagner |
spellingShingle |
Christine Sturm Anika E. Wagner Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways International Journal of Molecular Sciences Brassicaceae isothiocyanates sulforaphane Nrf2 NFκB epigenetics |
author_facet |
Christine Sturm Anika E. Wagner |
author_sort |
Christine Sturm |
title |
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways |
title_short |
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways |
title_full |
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways |
title_fullStr |
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways |
title_full_unstemmed |
Brassica-Derived Plant Bioactives as Modulators of Chemopreventive and Inflammatory Signaling Pathways |
title_sort |
brassica-derived plant bioactives as modulators of chemopreventive and inflammatory signaling pathways |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2017-09-01 |
description |
A high consumption of vegetables belonging to the Brassicaceae family has been related to a lower incidence of chronic diseases including different kinds of cancer. These beneficial effects of, e.g., broccoli, cabbage or rocket (arugula) intake have been mainly dedicated to the sulfur-containing glucosinolates (GLSs)—secondary plant compounds nearly exclusively present in Brassicaceae—and in particular to their bioactive breakdown products including isothiocyanates (ITCs). Overall, the current literature indicate that selected Brassica-derived ITCs exhibit health-promoting effects in vitro, as well as in laboratory mice in vivo. Some studies suggest anti-carcinogenic and anti-inflammatory properties for ITCs which may be communicated through an activation of the redox-sensitive transcription factor nuclear factor erythroid 2–related factor 2 (Nrf2) that controls the expression of antioxidant and phase II enzymes. Furthermore, it has been shown that ITCs are able to significantly ameliorate a severe inflammatory phenotype in colitic mice in vivo. As there are studies available suggesting an epigenetic mode of action for Brassica-derived phytochemicals, the conduction of further studies would be recommendable to investigate if the beneficial effects of these compounds also persist during an irregular consumption pattern. |
topic |
Brassicaceae isothiocyanates sulforaphane Nrf2 NFκB epigenetics |
url |
https://www.mdpi.com/1422-0067/18/9/1890 |
work_keys_str_mv |
AT christinesturm brassicaderivedplantbioactivesasmodulatorsofchemopreventiveandinflammatorysignalingpathways AT anikaewagner brassicaderivedplantbioactivesasmodulatorsofchemopreventiveandinflammatorysignalingpathways |
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