Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements
Here, using cryo-EM and smFRET, Henderson et al. show how tryptophan 571 in the HIV-1 Env acts as a conformational switch during receptor-mediated viral entry and design HIV-1 Env proteins that cannot undergo conformational changes. This has important implications for HIV-1 vaccine design.
Bibliographic Details
Main Authors: |
Rory Henderson,
Maolin Lu,
Ye Zhou,
Zekun Mu,
Robert Parks,
Qifeng Han,
Allen L. Hsu,
Elizabeth Carter,
Scott C. Blanchard,
R J Edwards,
Kevin Wiehe,
Kevin O. Saunders,
Mario J. Borgnia,
Alberto Bartesaghi,
Walther Mothes,
Barton F. Haynes,
Priyamvada Acharya,
S. Munir Alam |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2020-01-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/s41467-019-14196-w
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