HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy

HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy

A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole.Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatmen...

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Main Authors: Andrea Mazzella, Neil R.H. Stone, Erica R.M. Pool, Ana García Mingo, Sorina Bolache, Chris Wood
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Medical Mycology Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211753919301307
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spelling doaj-66b3bb9ca9a3429f89871240d49be0a72020-11-25T03:19:38ZengElsevierMedical Mycology Case Reports2211-75392020-03-01274243HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapyAndrea Mazzella0Neil R.H. Stone1Erica R.M. Pool2Ana García Mingo3Sorina Bolache4Chris Wood5Alexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UK; Corresponding author. Present address: London School of Hygiene & Tropical Medicine, Keppel Street, WC1E 7HT, London, UK.Alexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UKAlexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UK; University College London, Gower Street, WC1E 6BT, London, UKAlexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UKAlexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UKAlexander Pringle Centre, North Middlesex University Hospital, Sterling Way, N18 1QX, London, UKA 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole.Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatment was switched to oral isavuconazole; since then the patient has remained well. Keywords: Histoplasmosis, Isavuconazole, Itraconazole, HIV, Histoplasma capsulatumhttp://www.sciencedirect.com/science/article/pii/S2211753919301307
collection DOAJ
language English
format Article
sources DOAJ
author Andrea Mazzella
Neil R.H. Stone
Erica R.M. Pool
Ana García Mingo
Sorina Bolache
Chris Wood
spellingShingle Andrea Mazzella
Neil R.H. Stone
Erica R.M. Pool
Ana García Mingo
Sorina Bolache
Chris Wood
HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
Medical Mycology Case Reports
author_facet Andrea Mazzella
Neil R.H. Stone
Erica R.M. Pool
Ana García Mingo
Sorina Bolache
Chris Wood
author_sort Andrea Mazzella
title HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_short HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_full HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_fullStr HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_full_unstemmed HIV-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
title_sort hiv-associated disseminated histoplasmosis successfully treated with isavuconazole consolidation therapy
publisher Elsevier
series Medical Mycology Case Reports
issn 2211-7539
publishDate 2020-03-01
description A 30-year-old man with advanced HIV and disseminated histoplasmosis deteriorated after stepping down from intravenous liposomal amphotericin B to itraconazole.Therapeutic levels of itraconazole and posaconazole were not achieved, therefore liposomal amphotericin B was reintroduced. Stepdown treatment was switched to oral isavuconazole; since then the patient has remained well. Keywords: Histoplasmosis, Isavuconazole, Itraconazole, HIV, Histoplasma capsulatum
url http://www.sciencedirect.com/science/article/pii/S2211753919301307
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