Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy
Abstract Background Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to pla...
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doaj-66b6e01e61c24efbb6397d575c0ce3212021-01-10T13:02:57ZengBMCRadiation Oncology1748-717X2020-01-011511710.1186/s13014-019-1456-0Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapyYang Tang0Li Yang1Wan Qin2Min’ Xiao Yi3Bo Liu4Xiang’Lin Yuan5Department of Oncology, Tongji Hospital, Huazhong University of Science and TechnologyDepartment of Hematology, Tongji Hospital, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Huazhong University of Science and TechnologyDepartment of Oncology, Tongji Hospital, Huazhong University of Science and TechnologyAbstract Background Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to play regulatory role in inflammation and influence the phenotype and activity of fibroblasts. In this study, we aimed to evaluate the impact of HIPK2 gene variant on risk of radiation pneumonitis for patients with pulmonary malignancies. Methods 169 lung cancer patients with radiotherapy were included in our prospective study and genotyped by Sanger Sequence method. Multivariable Cox hazard analysis and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of all factors possibly related to the risk of radiation pneumonitis (RP). Results Patients with Mean Lung Dose (MLD) ≥ 15Gy, Lung V20 ≥ 24% had higher risk of RP ≥ grade 2 compared with those counterparts (HR = 1.888, 95% CI: 1.186–3.004, P = 0.007; HR = 2.126, 95% CI: 1.338–3.378, P = 0.001, respectively). Importantly, CC genotype of HIPK2: rs2030712 were strongly related to an increased occurrence of RP ≥ grade 2 (HR = 2.146, 95% CI: 1.215–3.791, P = 0.009). Conclusion HIPK2: rs2030712 was found to be significantly related to RP of grade ≥ 2 in our cohort, and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in larger population. Trial registration Our study was prospective and observational. The research was registered in ClinicalTrials.gov database as NCT02490319.https://doi.org/10.1186/s13014-019-1456-0Radiation pneumonitisLung cancerHIPK2SNP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yang Tang Li Yang Wan Qin Min’ Xiao Yi Bo Liu Xiang’Lin Yuan |
spellingShingle |
Yang Tang Li Yang Wan Qin Min’ Xiao Yi Bo Liu Xiang’Lin Yuan Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy Radiation Oncology Radiation pneumonitis Lung cancer HIPK2 SNP |
author_facet |
Yang Tang Li Yang Wan Qin Min’ Xiao Yi Bo Liu Xiang’Lin Yuan |
author_sort |
Yang Tang |
title |
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
title_short |
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
title_full |
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
title_fullStr |
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
title_full_unstemmed |
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
title_sort |
impact of genetic variant of hipk2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy |
publisher |
BMC |
series |
Radiation Oncology |
issn |
1748-717X |
publishDate |
2020-01-01 |
description |
Abstract Background Homeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to play regulatory role in inflammation and influence the phenotype and activity of fibroblasts. In this study, we aimed to evaluate the impact of HIPK2 gene variant on risk of radiation pneumonitis for patients with pulmonary malignancies. Methods 169 lung cancer patients with radiotherapy were included in our prospective study and genotyped by Sanger Sequence method. Multivariable Cox hazard analysis and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of all factors possibly related to the risk of radiation pneumonitis (RP). Results Patients with Mean Lung Dose (MLD) ≥ 15Gy, Lung V20 ≥ 24% had higher risk of RP ≥ grade 2 compared with those counterparts (HR = 1.888, 95% CI: 1.186–3.004, P = 0.007; HR = 2.126, 95% CI: 1.338–3.378, P = 0.001, respectively). Importantly, CC genotype of HIPK2: rs2030712 were strongly related to an increased occurrence of RP ≥ grade 2 (HR = 2.146, 95% CI: 1.215–3.791, P = 0.009). Conclusion HIPK2: rs2030712 was found to be significantly related to RP of grade ≥ 2 in our cohort, and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in larger population. Trial registration Our study was prospective and observational. The research was registered in ClinicalTrials.gov database as NCT02490319. |
topic |
Radiation pneumonitis Lung cancer HIPK2 SNP |
url |
https://doi.org/10.1186/s13014-019-1456-0 |
work_keys_str_mv |
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