Molecular Mechanisms Regulating T Helper 1 versus T Follicular Helper Cell Differentiation in Humans

IL-12 is important for the differentiation of T follicular helper (Tfh) cells, as well as Th1 cells in humans. Still, how IL-12 signals regulate Tfh versus Th1 cell differentiation remains poorly characterized. Here we aimed to determine the molecular mechanisms that regulate the differentiation and...

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Bibliographic Details
Main Authors: Nathalie Schmitt, Yang Liu, Salah-Eddine Bentebibel, Hideki Ueno
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308178