Anti-annexin V Antibodies in Women with Recurrent Miscarriage
Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriag...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
SAGE Publishing
2010-01-01
|
Series: | Clinical Medicine Insights: Reproductive Health |
Online Access: | https://doi.org/10.4137/CMRH.S5835 |
id |
doaj-66d1031dfdf044cbb62fb77a21fc6e0a |
---|---|
record_format |
Article |
spelling |
doaj-66d1031dfdf044cbb62fb77a21fc6e0a2020-11-25T03:32:42ZengSAGE PublishingClinical Medicine Insights: Reproductive Health1179-55812010-01-01410.4137/CMRH.S5835Anti-annexin V Antibodies in Women with Recurrent MiscarriageM.N. EL-Gharib0T.M. Elhawary1S.H. Elshourbagy2M.A. Morad3Departments of Obstetrics and Gynecology, Tanta, Egypt.Departments of Obstetrics and Gynecology, Tanta, Egypt.Departments of Obstetrics and Gynecology, Tanta, Egypt.Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results The mean value of a-A5 was 11.37 ± 6.78, 7.7 ± 1.40 and 6.20 ± 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ± 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage.https://doi.org/10.4137/CMRH.S5835 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
M.N. EL-Gharib T.M. Elhawary S.H. Elshourbagy M.A. Morad |
spellingShingle |
M.N. EL-Gharib T.M. Elhawary S.H. Elshourbagy M.A. Morad Anti-annexin V Antibodies in Women with Recurrent Miscarriage Clinical Medicine Insights: Reproductive Health |
author_facet |
M.N. EL-Gharib T.M. Elhawary S.H. Elshourbagy M.A. Morad |
author_sort |
M.N. EL-Gharib |
title |
Anti-annexin V Antibodies in Women with Recurrent Miscarriage |
title_short |
Anti-annexin V Antibodies in Women with Recurrent Miscarriage |
title_full |
Anti-annexin V Antibodies in Women with Recurrent Miscarriage |
title_fullStr |
Anti-annexin V Antibodies in Women with Recurrent Miscarriage |
title_full_unstemmed |
Anti-annexin V Antibodies in Women with Recurrent Miscarriage |
title_sort |
anti-annexin v antibodies in women with recurrent miscarriage |
publisher |
SAGE Publishing |
series |
Clinical Medicine Insights: Reproductive Health |
issn |
1179-5581 |
publishDate |
2010-01-01 |
description |
Objective To determine the role of anti-annexin V antibodies (a-A5) as an etiologic factor in recurrent pregnancy failure. Study design Prospective observational study. Material and methods The study included ninety first trimester pregnant women who had a history of unexplained recurrent miscarriage (group I) with ninety well-matched pregnant women with a history of normal reproductive outcome allocated as control group (GII) and another ninety nonpregnant women (GIII). Sera from all women controls were analyzed for anti-annexin antibody measured by Elisa. Results The mean value of a-A5 was 11.37 ± 6.78, 7.7 ± 1.40 and 6.20 ± 0.95 ng/ml in groups I, II and III respectively. There was a significant increase in the mean value a-A5 among women with a history of recurrent miscarriage, compared with controls. The mean value was 13.92 ± 2.42 ng/ml among patients with unfavourable outcome, compared with a corresponding value of 6.95 V 0.58 ng/ml among women with favourable outcome. The receiver operator characteristic curve revealed that the cutoff value of a-A5 was 8.61 ng/ml. Conclusion This study emphasizes the relationship between anti-annexin V antibodies and recurrent miscarriage. |
url |
https://doi.org/10.4137/CMRH.S5835 |
work_keys_str_mv |
AT mnelgharib antiannexinvantibodiesinwomenwithrecurrentmiscarriage AT tmelhawary antiannexinvantibodiesinwomenwithrecurrentmiscarriage AT shelshourbagy antiannexinvantibodiesinwomenwithrecurrentmiscarriage AT mamorad antiannexinvantibodiesinwomenwithrecurrentmiscarriage |
_version_ |
1724566508557828096 |