HIV-associated cardiovascular pathology

• Main Authors: N. A. Koziolova, O. G. Goryacheva, N. A. Terekhina
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2019-11-01
• Series: Российский кардиологический журнал
• Subjects: cardiovascular pathology; human immunodeficiency virus
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/3196

The  review presents the  rationale  for  studying  cardiovascular  disease in HIV-infected patients, as well as the importance of specific therapy. The embrace of this problem is due the widespread use of antiretroviral therapy in the world over the past 20  years  has  led  to  an  increase   in the  life expectancy   of HIV  patients,  while cardiovascular  diseases have become a mortality and disability leader.  The review presents the most frequently reported  cardiovascular pathology and cardiac complications  in HIV  patients  that  occur  both  against  the  background of virus-mediated  action and as a result of antiretroviral therapy. Some pathogenetic mechanisms of HIV influence on cardiomyocytes and the extracellular matrix have been  demonstrated, resulting in early heart  failure and  pulmonary hypertension. Information is given on the role of statins in the management of HIV patients with the clinically significant atherosclerosis.