Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier
The usefulness of pH-sensitive fusogenic polymer-(succinylated poly(glycidol)-(SucPG-) modified liposomes as a vaccine carrier in the induction of immune responses was evaluated. Mice were intraperitoneally immunized with ovalbumin- (OVA-) containing SucPG-modified liposomes. After immunization, sig...
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doaj-66ec9c90eaf244049b273964138c5ee92020-11-24T22:09:35ZengHindawi LimitedThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/903234903234Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine CarrierShinobu Watarai0Tana Iwase1Tomoko Tajima2Eiji Yuba3Kenji Kono4Division of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, JapanDivision of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, JapanDivision of Veterinary Science, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, Izumisano, Osaka 598-8531, JapanDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanDepartment of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka 599-8531, JapanThe usefulness of pH-sensitive fusogenic polymer-(succinylated poly(glycidol)-(SucPG-) modified liposomes as a vaccine carrier in the induction of immune responses was evaluated. Mice were intraperitoneally immunized with ovalbumin- (OVA-) containing SucPG-modified liposomes. After immunization, significant OVA-specific antibodies were detected in the serum. When sera were analyzed for isotype distribution, OVA-specific IgG1 antibody responses were noted in mice immunized with OVA-containing polymer-unmodified liposomes, whereas immunization with OVA-containing SucPG-modified liposomes resulted in the induction of OVA-specific IgG1, IgG2a, and IgG3 Ab responses. In spleen lymphocytes from mice immunized with OVA-containing SucPG-modified liposomes, both IFN-γ-(Th1-type-) and IL-4-(Th2 type-) specific mRNA were detected. Moreover, substantial production of IFN-γ and IL-4 was demonstrated in spleen cells from OVA-containing SucPG-modified liposomes in vitro. These results suggest that the pH-sensitive fusogenic polymer-(SucPG-) modified liposomes would serve effectively as an antigen delivery vehicle for inducing Th1 and Th2 immune responses.http://dx.doi.org/10.1155/2013/903234 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shinobu Watarai Tana Iwase Tomoko Tajima Eiji Yuba Kenji Kono |
spellingShingle |
Shinobu Watarai Tana Iwase Tomoko Tajima Eiji Yuba Kenji Kono Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier The Scientific World Journal |
author_facet |
Shinobu Watarai Tana Iwase Tomoko Tajima Eiji Yuba Kenji Kono |
author_sort |
Shinobu Watarai |
title |
Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier |
title_short |
Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier |
title_full |
Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier |
title_fullStr |
Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier |
title_full_unstemmed |
Efficiency of pH-Sensitive Fusogenic Polymer-Modified Liposomes as a Vaccine Carrier |
title_sort |
efficiency of ph-sensitive fusogenic polymer-modified liposomes as a vaccine carrier |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
1537-744X |
publishDate |
2013-01-01 |
description |
The usefulness of pH-sensitive fusogenic polymer-(succinylated poly(glycidol)-(SucPG-) modified liposomes as a vaccine carrier in the induction of immune responses was evaluated. Mice were intraperitoneally immunized with ovalbumin- (OVA-) containing SucPG-modified liposomes. After immunization, significant OVA-specific antibodies were detected in the serum. When sera were analyzed for isotype distribution, OVA-specific IgG1 antibody responses were noted in mice immunized with OVA-containing polymer-unmodified liposomes, whereas immunization with OVA-containing SucPG-modified liposomes resulted in the induction of OVA-specific IgG1, IgG2a, and IgG3 Ab responses. In spleen lymphocytes from mice immunized with OVA-containing SucPG-modified liposomes, both IFN-γ-(Th1-type-) and IL-4-(Th2 type-) specific mRNA were detected. Moreover, substantial production of IFN-γ and IL-4 was demonstrated in spleen cells from OVA-containing SucPG-modified liposomes in vitro. These results suggest that the pH-sensitive fusogenic polymer-(SucPG-) modified liposomes would serve effectively as an antigen delivery vehicle for inducing Th1 and Th2 immune responses. |
url |
http://dx.doi.org/10.1155/2013/903234 |
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