Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma
<sup>123</sup>I-meta-iodobenzylguanidine (<sup>123</sup>I-mIBG) scintigraphy is used for evaluating disease extent in children with neuroblastoma. <sup>131</sup>I-mIBG therapy has been used for evaluation in children with high-risk neuroblastoma, and post-therapy...
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Format: | Article |
Language: | English |
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MDPI AG
2020-09-01
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Series: | Diagnostics |
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Online Access: | https://www.mdpi.com/2075-4418/10/9/663 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroshi Wakabayashi Daiki Kayano Anri Inaki Raita Araki Rie Kuroda Norihito Akatani Takafumi Yamase Satoru Watanabe Tomo Hiromasa Yuji Kunita Hiroshi Mori Shintaro Saito Yasuhiro Ikawa Toshihiro Fujiki Seigo Kinuya |
spellingShingle |
Hiroshi Wakabayashi Daiki Kayano Anri Inaki Raita Araki Rie Kuroda Norihito Akatani Takafumi Yamase Satoru Watanabe Tomo Hiromasa Yuji Kunita Hiroshi Mori Shintaro Saito Yasuhiro Ikawa Toshihiro Fujiki Seigo Kinuya Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma Diagnostics diagnostic <sup>123</sup>I-mIBG scintigraphy post-therapeutic <sup>131</sup>I-mIBG scintigraphy high-risk neuroblastoma consolidation therapy |
author_facet |
Hiroshi Wakabayashi Daiki Kayano Anri Inaki Raita Araki Rie Kuroda Norihito Akatani Takafumi Yamase Satoru Watanabe Tomo Hiromasa Yuji Kunita Hiroshi Mori Shintaro Saito Yasuhiro Ikawa Toshihiro Fujiki Seigo Kinuya |
author_sort |
Hiroshi Wakabayashi |
title |
Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma |
title_short |
Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma |
title_full |
Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma |
title_fullStr |
Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma |
title_full_unstemmed |
Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma |
title_sort |
diagnostic use of post-therapy <sup>131</sup>i-meta-iodobenzylguanidine scintigraphy in consolidation therapy for children with high-risk neuroblastoma |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2020-09-01 |
description |
<sup>123</sup>I-meta-iodobenzylguanidine (<sup>123</sup>I-mIBG) scintigraphy is used for evaluating disease extent in children with neuroblastoma. <sup>131</sup>I-mIBG therapy has been used for evaluation in children with high-risk neuroblastoma, and post-therapy <sup>131</sup>I-mIBG scintigraphy may detect more lesions compared with diagnostic <sup>123</sup>I-mIBG scintigraphy. However, no studies have yet revealed the detection rate of hidden mIBG-avid lesions on post-therapy <sup>131</sup>I-mIBG whole-body scan (WBS) and SPECT images in neuroblastoma children without mIBG-avid lesions as demonstrated by diagnostic <sup>123</sup>I-mIBG scintigraphy. We retrospectively examined the diagnostic utility of post-therapy <sup>131</sup>I-mIBG scintigraphy in children who received <sup>131</sup>I-mIBG as consolidation therapy. Nineteen children with complete response to primary therapy were examined. Post-therapy <sup>131</sup>I-mIBG scintigraphy was performed four days after injection. The post-therapy <sup>131</sup>I-mIBG scintigraphy, 4 children exhibited abnormal uptake on the WBS. Post-therapy <sup>131</sup>I-mIBG SPECT/CT provided additional information in 2 cases. In total, 6 children exhibited abnormal uptake. The site of abnormal accumulation was on the recurrence site in one case, operation sites in five cases, and bone metastasis in one case. Post-therapy <sup>131</sup>I-mIBG scintigraphy could detect residual disease that was not recognized using diagnostic <sup>123</sup>I-mIBG scintigraphy in 32% of children with high-risk neuroblastoma and ganglioneuroblastoma. The diagnostic use of post-therapy <sup>131</sup>I-mIBG scintigraphy can provide valuable information for detecting residual disease. |
topic |
diagnostic <sup>123</sup>I-mIBG scintigraphy post-therapeutic <sup>131</sup>I-mIBG scintigraphy high-risk neuroblastoma consolidation therapy |
url |
https://www.mdpi.com/2075-4418/10/9/663 |
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doaj-66f78a23b1f946638aa7f886539e70622020-11-25T03:18:08ZengMDPI AGDiagnostics2075-44182020-09-011066366310.3390/diagnostics10090663Diagnostic Use of Post-therapy <sup>131</sup>I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk NeuroblastomaHiroshi Wakabayashi0Daiki Kayano1Anri Inaki2Raita Araki3Rie Kuroda4Norihito Akatani5Takafumi Yamase6Satoru Watanabe7Tomo Hiromasa8Yuji Kunita9Hiroshi Mori10Shintaro Saito11Yasuhiro Ikawa12Toshihiro Fujiki13Seigo Kinuya14Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Pediatrics, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Pediatrics, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Pediatrics, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Pediatrics, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, JapanDepartment of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, Ishikawa 920-8641, Japan<sup>123</sup>I-meta-iodobenzylguanidine (<sup>123</sup>I-mIBG) scintigraphy is used for evaluating disease extent in children with neuroblastoma. <sup>131</sup>I-mIBG therapy has been used for evaluation in children with high-risk neuroblastoma, and post-therapy <sup>131</sup>I-mIBG scintigraphy may detect more lesions compared with diagnostic <sup>123</sup>I-mIBG scintigraphy. However, no studies have yet revealed the detection rate of hidden mIBG-avid lesions on post-therapy <sup>131</sup>I-mIBG whole-body scan (WBS) and SPECT images in neuroblastoma children without mIBG-avid lesions as demonstrated by diagnostic <sup>123</sup>I-mIBG scintigraphy. We retrospectively examined the diagnostic utility of post-therapy <sup>131</sup>I-mIBG scintigraphy in children who received <sup>131</sup>I-mIBG as consolidation therapy. Nineteen children with complete response to primary therapy were examined. Post-therapy <sup>131</sup>I-mIBG scintigraphy was performed four days after injection. The post-therapy <sup>131</sup>I-mIBG scintigraphy, 4 children exhibited abnormal uptake on the WBS. Post-therapy <sup>131</sup>I-mIBG SPECT/CT provided additional information in 2 cases. In total, 6 children exhibited abnormal uptake. The site of abnormal accumulation was on the recurrence site in one case, operation sites in five cases, and bone metastasis in one case. Post-therapy <sup>131</sup>I-mIBG scintigraphy could detect residual disease that was not recognized using diagnostic <sup>123</sup>I-mIBG scintigraphy in 32% of children with high-risk neuroblastoma and ganglioneuroblastoma. The diagnostic use of post-therapy <sup>131</sup>I-mIBG scintigraphy can provide valuable information for detecting residual disease.https://www.mdpi.com/2075-4418/10/9/663diagnostic <sup>123</sup>I-mIBG scintigraphypost-therapeutic <sup>131</sup>I-mIBG scintigraphyhigh-risk neuroblastomaconsolidation therapy |