BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer developm...

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Main Authors: Min Liu, Tongyu Sun, Ni Li, Junjie Peng, Da Fu, Wei Li, Li Li, Wei-Qiang Gao
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12573-z
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spelling doaj-670a91c070094d66a9b1c64d04f3c4c22021-05-11T12:11:04ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12573-zBRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestrationMin Liu0Tongyu Sun1Ni Li2Junjie Peng3Da Fu4Wei Li5Li Li6Wei-Qiang Gao7State Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityCAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of SciencesCAS Key Laboratory of Tissue Microenvironment and Tumor, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of SciencesDepartment of Colorectal Surgery, Fudan University Shanghai Cancer CenterCentral Laboratory for Medical Research, Shanghai Tenth People’s Hospital, Tongji University School of MedicineState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityState Key Laboratory of Oncogenes and Related Genes, Renji-Med X Clinical Stem Cell Research Center, Ren Ji Hospital, School of Medicine and School of Biomedical Engineering, Shanghai Jiao Tong UniversityDysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer development.https://doi.org/10.1038/s41467-019-12573-z
collection DOAJ
language English
format Article
sources DOAJ
author Min Liu
Tongyu Sun
Ni Li
Junjie Peng
Da Fu
Wei Li
Li Li
Wei-Qiang Gao
spellingShingle Min Liu
Tongyu Sun
Ni Li
Junjie Peng
Da Fu
Wei Li
Li Li
Wei-Qiang Gao
BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
Nature Communications
author_facet Min Liu
Tongyu Sun
Ni Li
Junjie Peng
Da Fu
Wei Li
Li Li
Wei-Qiang Gao
author_sort Min Liu
title BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_short BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_full BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_fullStr BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_full_unstemmed BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
title_sort brg1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Dysfunctional autophagy induces inflammation that contributes to tumorigenesis. Here, the authors show that loss of BRG1 impairs autophagy and enhances reactive oxygen species production to disrupt intestinal barrier integrity, leading to spontaneous colitis and subsequent colorectal cancer development.
url https://doi.org/10.1038/s41467-019-12573-z
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