Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16590-1 |
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doaj-670b26b5d219499083d912a34bb1bf002021-06-06T11:16:27ZengNature Publishing GroupNature Communications2041-17232020-06-0111111610.1038/s41467-020-16590-1Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanomaJiyeon Choi0Tongwu Zhang1Andrew Vu2Julien Ablain3Matthew M. Makowski4Leandro M. Colli5Mai Xu6Rebecca C. Hennessey7Jinhu Yin8Harriet Rothschild9Cathrin Gräwe10Michael A. Kovacs11Karen M. Funderburk12Myriam Brossard13John Taylor14Bogdan Pasaniuc15Raj Chari16Stephen J. Chanock17Clive J. Hoggart18Florence Demenais19Jennifer H. Barrett20Matthew H. Law21Mark M. Iles22Kai Yu23Michiel Vermeulen24Leonard I. Zon25Kevin M. Brown26Division of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer InstituteDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University NijmegenDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer InstituteDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University NijmegenDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteUniversité de Paris, UMRS-1124, Institut National de la Santé et de la Recherche Médicale (INSERM)Leeds Institute for Data Analytics, School of Medicine, University of LeedsDepartment of Human Genetics, David Geffen School of Medicine, University of California, Los AngelesGenome Modification Core, Frederick National Lab for Cancer Research, National Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Medicine, Imperial College LondonUniversité de Paris, UMRS-1124, Institut National de la Santé et de la Recherche Médicale (INSERM)Leeds Institute for Data Analytics, School of Medicine, University of LeedsStatistical Genetics, QIMR Berghofer Medical Research InstituteLeeds Institute for Data Analytics, School of Medicine, University of LeedsDivision of Cancer Epidemiology and Genetics, National Cancer InstituteDepartment of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Oncode Institute, Radboud University NijmegenStem Cell Program and Division of Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer InstituteThere are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model.https://doi.org/10.1038/s41467-020-16590-1 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown |
| spellingShingle |
Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma Nature Communications |
| author_facet |
Jiyeon Choi Tongwu Zhang Andrew Vu Julien Ablain Matthew M. Makowski Leandro M. Colli Mai Xu Rebecca C. Hennessey Jinhu Yin Harriet Rothschild Cathrin Gräwe Michael A. Kovacs Karen M. Funderburk Myriam Brossard John Taylor Bogdan Pasaniuc Raj Chari Stephen J. Chanock Clive J. Hoggart Florence Demenais Jennifer H. Barrett Matthew H. Law Mark M. Iles Kai Yu Michiel Vermeulen Leonard I. Zon Kevin M. Brown |
| author_sort |
Jiyeon Choi |
| title |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_short |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_full |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_fullStr |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_full_unstemmed |
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma |
| title_sort |
massively parallel reporter assays of melanoma risk variants identify mx2 as a gene promoting melanoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-06-01 |
| description |
There are more than 20 known melanoma susceptibility genes. Here, using a massively parallel reporter assay, the authors identify risk-associated variants that alter gene transcription, and demonstrate that expression of one such gene, MX2, leads to the promotion of melanoma in a zebrafish model. |
| url |
https://doi.org/10.1038/s41467-020-16590-1 |
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