The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method
Introduction: Bone scan is a nuclear medicine scan test, which leads to finding specific abnormalities in the bone. Methylene Diphosphonate (MDP) is used to bone scan. This combination is absorbed by bone tissue and is excreted by the kidneys and bladder. The purpose of this study was to estimate th...
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Shahid Sadoughi University of Medical Sciences
2018-10-01
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doaj-67139ee63b244238aa4c747957ea87b82020-11-25T00:29:27ZfasShahid Sadoughi University of Medical SciencesMajallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd2228-57412228-57332018-10-01266463472The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid methodsedighe taghizade0aliasghar parach1kazem Razavi-Ratki2mahmoud bagheri3 Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Research Center for Nuclear Medicine, Tehran University of Medical Sciences, Tehran, Iran Department of Medical Physics and Biomedical Engineering, Tehran University of Medical Sciences, Tehran,Iran Introduction: Bone scan is a nuclear medicine scan test, which leads to finding specific abnormalities in the bone. Methylene Diphosphonate (MDP) is used to bone scan. This combination is absorbed by bone tissue and is excreted by the kidneys and bladder. The purpose of this study was to estimate the absorbed dose of organs in bone scan with injection MDP radiopharmaceutical using Mirdose software and the SPECT/planar hybrid method. Methods: 20 females who referred to the Nuclear Medicine Department for bone disorders were examined and three planar images intervals of 1, 3 and 5 hours and one SPECT at 3 hours after injection were taken from them. The cumulative activity of the organs was obtained using the SPECT/planar hybrid method and then the absorbed dose was calculated using Mirdose software. Results: The mean absorbed dose due to 99mTc-MDP in women for heart wall (0.0026±0.0005), kidneys (0.043± 0.0072), liver (0.0034±0.0001), lungs (0.0024±0.0001), muscle (0.0028±0.0006), ovaries (0.0056±0.0004), spleen (0.0048±0.0003), urinary bladder wall (0.0680±0.0120), bones (0.0046± 0.0006) and reminder of the body (0.0031± 0.00098) mGy/MBq were obtained. Conclusion: Bladder, kidneys, ovaries, spleen, bones, liver, muscles, walls of the heart and lungs have the highest rates of absorbed dose in organs, respectively.Since the women studied in this study had different diseases and bone disorders and biological characteristics, and some of them were metastatic due to the disease, this led to a different absorption of radiopharmaceuticals in the various organs of these patients, which caused the difference is in the average absorbed dose of radiopharmaceuticals in their organs. http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3376-1&slc_lang=en&sid=1Internal absorbed dose Combined SPECT/Planar method Mirdose software Cumulated activity. |
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sedighe taghizade aliasghar parach kazem Razavi-Ratki mahmoud bagheri |
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sedighe taghizade aliasghar parach kazem Razavi-Ratki mahmoud bagheri The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd Internal absorbed dose Combined SPECT/Planar method Mirdose software Cumulated activity. |
author_facet |
sedighe taghizade aliasghar parach kazem Razavi-Ratki mahmoud bagheri |
author_sort |
sedighe taghizade |
title |
The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method |
title_short |
The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method |
title_full |
The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method |
title_fullStr |
The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method |
title_full_unstemmed |
The estimation of body organs absorbed dose induced by 99mTc –MDP radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/SPECT hybrid method |
title_sort |
estimation of body organs absorbed dose induced by 99mtc –mdp radiopharmaceutical in the patients undergoing bone scan by specific dosimetry and planar/spect hybrid method |
publisher |
Shahid Sadoughi University of Medical Sciences |
series |
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd |
issn |
2228-5741 2228-5733 |
publishDate |
2018-10-01 |
description |
Introduction: Bone scan is a nuclear medicine scan test, which leads to finding specific abnormalities in the bone. Methylene Diphosphonate (MDP) is used to bone scan. This combination is absorbed by bone tissue and is excreted by the kidneys and bladder. The purpose of this study was to estimate the absorbed dose of organs in bone scan with injection MDP radiopharmaceutical using Mirdose software and the SPECT/planar hybrid method.
Methods: 20 females who referred to the Nuclear Medicine Department for bone disorders were examined and three planar images intervals of 1, 3 and 5 hours and one SPECT at 3 hours after injection were taken from them. The cumulative activity of the organs was obtained using the SPECT/planar hybrid method and then the absorbed dose was calculated using Mirdose software.
Results: The mean absorbed dose due to 99mTc-MDP in women for heart wall (0.0026±0.0005), kidneys (0.043± 0.0072), liver (0.0034±0.0001), lungs (0.0024±0.0001), muscle (0.0028±0.0006), ovaries (0.0056±0.0004), spleen (0.0048±0.0003), urinary bladder wall (0.0680±0.0120), bones (0.0046± 0.0006) and reminder of the body (0.0031± 0.00098) mGy/MBq were obtained.
Conclusion: Bladder, kidneys, ovaries, spleen, bones, liver, muscles, walls of the heart and lungs have the highest rates of absorbed dose in organs, respectively.Since the women studied in this study had different diseases and bone disorders and biological characteristics, and some of them were metastatic due to the disease, this led to a different absorption of radiopharmaceuticals in the various organs of these patients, which caused the difference is in the average absorbed dose of radiopharmaceuticals in their organs.
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topic |
Internal absorbed dose Combined SPECT/Planar method Mirdose software Cumulated activity. |
url |
http://jssu.ssu.ac.ir/browse.php?a_code=A-10-3376-1&slc_lang=en&sid=1 |
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