An update on oral drug delivery via intestinal lymphatic transport

• Main Authors: Zichen Zhang, Yi Lu, Jianping Qi, Wei Wu
• Format: Article
• Language: English
• Published: Elsevier 2021-08-01
• Series: Acta Pharmaceutica Sinica B
• Subjects: Drug delivery; Oral; Lymphatic transport; Drug absorption; Chylomicron; Microfold cell
• Online Access: http://www.sciencedirect.com/science/article/pii/S2211383521000344

Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.