An update on oral drug delivery via intestinal lymphatic transport
Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metab...
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2021-08-01
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doaj-67139eee30734117a7987d4b1ed017072021-09-01T04:20:57ZengElsevierActa Pharmaceutica Sinica B2211-38352021-08-0111824492468An update on oral drug delivery via intestinal lymphatic transportZichen Zhang0Yi Lu1Jianping Qi2Wei Wu3Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, ChinaKey Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Corresponding author. Tel./fax: +86 21 51980084.Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.http://www.sciencedirect.com/science/article/pii/S2211383521000344Drug deliveryOralLymphatic transportDrug absorptionChylomicronMicrofold cell |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zichen Zhang Yi Lu Jianping Qi Wei Wu |
spellingShingle |
Zichen Zhang Yi Lu Jianping Qi Wei Wu An update on oral drug delivery via intestinal lymphatic transport Acta Pharmaceutica Sinica B Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell |
author_facet |
Zichen Zhang Yi Lu Jianping Qi Wei Wu |
author_sort |
Zichen Zhang |
title |
An update on oral drug delivery via intestinal lymphatic transport |
title_short |
An update on oral drug delivery via intestinal lymphatic transport |
title_full |
An update on oral drug delivery via intestinal lymphatic transport |
title_fullStr |
An update on oral drug delivery via intestinal lymphatic transport |
title_full_unstemmed |
An update on oral drug delivery via intestinal lymphatic transport |
title_sort |
update on oral drug delivery via intestinal lymphatic transport |
publisher |
Elsevier |
series |
Acta Pharmaceutica Sinica B |
issn |
2211-3835 |
publishDate |
2021-08-01 |
description |
Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport—the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications. |
topic |
Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell |
url |
http://www.sciencedirect.com/science/article/pii/S2211383521000344 |
work_keys_str_mv |
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