The role of m6A modification in the biological functions and diseases
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA...
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Series: | Signal Transduction and Targeted Therapy |
Online Access: | https://doi.org/10.1038/s41392-020-00450-x |
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doaj-6713afd9239d44a7ad0a9b5c9cd8e10c2021-02-21T12:19:19ZengNature Publishing GroupSignal Transduction and Targeted Therapy2059-36352021-02-016111610.1038/s41392-020-00450-xThe role of m6A modification in the biological functions and diseasesXiulin Jiang0Baiyang Liu1Zhi Nie2Lincan Duan3Qiuxia Xiong4Zhixian Jin5Cuiping Yang6Yongbin Chen7Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyKunming Medical UniversityKunming Medical UniversityKunming Medical UniversityKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyKey Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of ZoologyAbstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the demethylases, or erasers, including FTO and ALKBH5. It is recognized by m6A-binding proteins YTHDF1/2/3, YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1, also known as “readers”. Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of different types of human cancers. In this review, we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems. We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation, its regulators and downstream target genes, during cancer progression in above systems. We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future.https://doi.org/10.1038/s41392-020-00450-x |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen |
spellingShingle |
Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen The role of m6A modification in the biological functions and diseases Signal Transduction and Targeted Therapy |
author_facet |
Xiulin Jiang Baiyang Liu Zhi Nie Lincan Duan Qiuxia Xiong Zhixian Jin Cuiping Yang Yongbin Chen |
author_sort |
Xiulin Jiang |
title |
The role of m6A modification in the biological functions and diseases |
title_short |
The role of m6A modification in the biological functions and diseases |
title_full |
The role of m6A modification in the biological functions and diseases |
title_fullStr |
The role of m6A modification in the biological functions and diseases |
title_full_unstemmed |
The role of m6A modification in the biological functions and diseases |
title_sort |
role of m6a modification in the biological functions and diseases |
publisher |
Nature Publishing Group |
series |
Signal Transduction and Targeted Therapy |
issn |
2059-3635 |
publishDate |
2021-02-01 |
description |
Abstract N6-methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic cells. m6A modification is modified by the m6A methyltransferases, or writers, such as METTL3/14/16, RBM15/15B, ZC3H3, VIRMA, CBLL1, WTAP, and KIAA1429, and, removed by the demethylases, or erasers, including FTO and ALKBH5. It is recognized by m6A-binding proteins YTHDF1/2/3, YTHDC1/2 IGF2BP1/2/3 and HNRNPA2B1, also known as “readers”. Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of different types of human cancers. In this review, we discuss how m6A RNA methylation influences both the physiological and pathological progressions of hematopoietic, central nervous and reproductive systems. We will mainly focus on recent progress in identifying the biological functions and the underlying molecular mechanisms of m6A RNA methylation, its regulators and downstream target genes, during cancer progression in above systems. We propose that m6A RNA methylation process offer potential targets for cancer therapy in the future. |
url |
https://doi.org/10.1038/s41392-020-00450-x |
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