| Summary: | <b>Introduction:</b> Outpatient total hip arthroplasty (THA) is increasingly popular. This meta-analysis investigated the potential advantages of outpatient regimes for THA. <b>Methods:</b> This study followed the PRISMA guidelines. PubMed, Web of Science, Google Scholar, Embase, and Scopus databases were accessed in June 2021. All clinical studies investigating outpatient THA were considered. The outcomes of interest were pain, infection, mortality, revision, dislocation, readmission rates, and deep vein thrombosis (DVT). <b>Results:</b> Data from 102,839 patients were included. A total of 52% (153,168 of 102,839 patients) were women. The mean age of patients was 62.6 ± 4.6 years, the mean BMI was 29.1 ± 1.8 kg/m<sup>2</sup>. Good comparability was found in age, BMI, and gender (<i>p</i> > 0.1). No difference was found in pain (<i>p</i> = 0.4), infections (<i>p</i> = 0.9), mortality (<i>p</i> = 0.9), rate of revision (<i>p</i> = 0.1), dislocation (<i>p</i> = 0.9), and readmission (<i>p</i> = 0.8). The outpatient group demonstrated a greater rate of DVT (OR 3.57; 95% CI 2.47 to 5.18; <i>p</i> < 0.0001). <b>Conclusions:</b> In selected patients, outpatient THA can be performed safely with optimal outcomes comparable with inpatient THA. Clear and comprehensive pre-operative planning should involve a multi-disciplinary group composed of orthopaedic surgeons, anaesthesia and rehabilitation specialists, and physiotherapists. Each centre performing outpatient THA should implement continuous homecoming welfare activity, to supervise physiotherapy and monitor anticoagulant therapy.
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