Role of Tet2 in Regulating Adaptive and Innate Immunity

Role of Tet2 in Regulating Adaptive and Innate Immunity

Accumulated evidence indicates that epigenetic modifications play central roles in gene expression regulation and participate in developing many autoimmune and autoinflammatory diseases. Mechanistically, epigenetic modifications act as a bridge between environmental and cellular factors and suscepti...

Full description

Bibliographic Details
Main Authors:	Jiaqi Li, Lifang Li, Xiaoxiao Sun, Tuo Deng, Gan Huang, Xia Li, Zhiguo Xie, Zhiguang Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	ten-eleven translocation-2 DNA methylation gene regulation and expression immune cell differentiation autoinflammatory and autoimmune diseases
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.665897/full

Similar Items

TET Enzymes and 5hmC in Adaptive and Innate Immune Systems
by: Chan-Wang J. Lio, et al.
Published: (2019-02-01)

Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
by: Michael Reimer, et al.
Published: (2019-07-01)

Glyphosate Primes Mammary Cells for Tumorigenesis by Reprogramming the Epigenome in a TET3-Dependent Manner
by: Manon Duforestel, et al.
Published: (2019-09-01)

Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hydralazine Attenuates Progression of Chronic Kidney Disease
by: Björn Tampe, et al.
Published: (2015-01-01)

The role of TET proteins in stress-induced neuroepigenetic and behavioural adaptations
by: Alec Dick, et al.
Published: (2021-11-01)

THE PROGNOSTIC SIGNIFICANCE OF TET2 SINGLE NUCLEOTIDE POLYMORPHISM IN EGYPTIAN CHRONIC MYELOID LEUKEMIA
by: Enas A Dammag, et al.
Published: (2020-01-01)

Molecular Evolution of the TET Gene Family in Mammals
by: Hiromichi Akahori, et al.
Published: (2015-12-01)

The Profiles of Tet-Mediated DNA Hydroxymethylation in Human Gliomas
by: Brągiel-Pieczonka, A., et al.
Published: (2022)

Cytosine hydroxymethylation by TET enzymes: From the control of gene expression to the regulation of DNA repair mechanisms, and back
by: Audrey Lejart, et al.
Published: (2018-09-01)

Ten-Eleven Translocation (TET) Enzymes Modulate the Activation of Dendritic Cells in Allergic Rhinitis
by: Hang Li, et al.
Published: (2019-09-01)

TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism
by: Xixia Zhang, et al.
Published: (2020-08-01)

SETDB1 prevents TET2-dependent activation of IAP retroelements in naïve embryonic stem cells
by: Özgen Deniz, et al.
Published: (2018-01-01)

Empagliflozin Alleviates Hepatic Steatosis by Activating the AMPK-TET2-Autophagy Pathway in vivo and in vitro
by: Ting Li, et al.
Published: (2021-01-01)

FREQUENCY OF TET2 GENE MUTATION IN MYELOPROLIFERATIVE NEOPLASMS
by: Syed Owais Ali, et al.
Published: (2021-04-01)

Exercise Ameliorates Spinal Cord Injury by Changing DNA Methylation
by: Ganchimeg Davaa, et al.
Published: (2021-01-01)

Alterations of 5-Hydroxymethylcytosine in Human Cancers
by: Ali Yesilkanal, et al.
Published: (2013-06-01)

Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1
by: Yi-lin Yan, et al.
Published: (2020-05-01)

Epigenetic induction of tumor stemness via the lipopolysaccharide-TET3-HOXB2 signaling axis in esophageal squamous cell carcinoma
by: Fengkai Xu, et al.
Published: (2020-02-01)

Proteins in DNA methylation and their role in neural stem cell proliferation and differentiation
by: Jiaqi Sun, et al.
Published: (2021-03-01)

The Roles of Base Modifications in Kidney Cancer
by: Chunyue Feng, et al.
Published: (2020-11-01)

Correlation of mutational landscape and survival outcome of peripheral T-cell lymphomas
by: Yingying Ye, et al.
Published: (2021-02-01)

SIRT1 Deacetylates TET2 and Promotes Its Ubiquitination Degradation to Achieve Neuroprotection Against Parkinson's Disease
by: Xuan Li, et al.
Published: (2021-04-01)

TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System
by: Juan Peng, et al.
Published: (2017-07-01)

Increased 5-hydroxymethylcytosine and Ten-eleven Translocation Protein Expression in Ultraviolet B-irradiated HaCaT Cells
by: Dan Wang, et al.
Published: (2017-01-01)

UVB induces cutaneous squamous cell carcinoma progression by de novo ID4 methylation via methylation regulating enzymes
by: Liming Li, et al.
Published: (2020-07-01)

Ascorbic Acid Promotes Plasma Cell Differentiation through Enhancing TET2/3-Mediated DNA Demethylation
by: Tuan Qi, et al.
Published: (2020-12-01)

Protective effects of astragaloside IV against hypertension-induced vascular remodeling involves the DNMT1 and TET2 signaling pathway
by: Qin Yingchun, et al.
Published: (2021-01-01)

MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling
by: Mariane Serra Fráguas, et al.
Published: (2017-03-01)

Multiple Functions of Ten-eleven Translocation 1 during Tumorigenesis
by: Yi-Ping Tian, et al.
Published: (2016-01-01)

Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions—benign adenomas and inflammatory bowel disease
by: Tomasz Dziaman, et al.
Published: (2018-05-01)

YTHDC2-Mediated circYTHDC2 N6-Methyladenosine Modification Promotes Vascular Smooth Muscle Cells Dysfunction Through Inhibiting Ten-Eleven Translocation 2
by: Jun Yuan, et al.
Published: (2021-10-01)

MicroRNA-210 downregulates TET2 and contributes to inflammatory response in neonatal hypoxic-ischemic brain injury
by: Qingyi Ma, et al.
Published: (2021-01-01)

Ascorbic acid increases demethylation in somatic cell nuclear transfer embryos of the pig ()
by: Minghui Zhao, et al.
Published: (2017-07-01)

The Emerging Nexus of Active DNA Demethylation and Mitochondrial Oxidative Metabolism in Post-Mitotic Neurons
by: Huan Meng, et al.
Published: (2014-12-01)

Alterations in the Genomic Distribution of 5hmC in In Vivo Aged Human Skin Fibroblasts
by: Paulina Kołodziej-Wojnar, et al.
Published: (2021-12-01)

Bridging autoinflammatory and autoimmune diseases
by: Emad M. El-Shebiny, et al.
Published: (2021-03-01)

Regulation and Functional Significance of 5-Hydroxymethylcytosine in Cancer
by: Vittal Rangan Arvinden, et al.
Published: (2017-11-01)

Behçet’s Disease in Children: Diagnostic and Management Challenges
by: Costagliola G, et al.
Published: (2020-06-01)

Primary systemic vasculitides as the bridge in immune-mediated disorders: small vessels for autoimmunity, medium vessels for autoinflammation
by: Tiago Borges, et al.
Published: (2021-01-01)

Rationale for a Combination Therapy with the STAT5 Inhibitor AC-4-130 and the MCL1 Inhibitor S63845 in the Treatment of FLT3-Mutated or TET2-Mutated Acute Myeloid Leukemia
by: Katja Seipel, et al.
Published: (2021-07-01)