Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study
<p>Abstract</p> <p>Background</p> <p>A new lower-cost rapid-throughput human papillomavirus (HPV) test (<it>care</it>HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia.&l...
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2011-06-01
|
Series: | BMC Cancer |
Online Access: | http://www.biomedcentral.com/1471-2407/11/239 |
id |
doaj-671926e99b5b4a4a982032a071ce1544 |
---|---|
record_format |
Article |
spelling |
doaj-671926e99b5b4a4a982032a071ce15442020-11-24T23:28:06ZengBMCBMC Cancer1471-24072011-06-0111123910.1186/1471-2407-11-239Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling studyKang Yoon-JungMa LiSimonella LeonardoNing YanLegood RosaZhao Fang-HuiLew Jie-BinCanfell KarenShi Ju-FangZhang Yong-ZhenSmith Megan AChen Jun-FengFeng Xiang-XianQiao You-Lin<p>Abstract</p> <p>Background</p> <p>A new lower-cost rapid-throughput human papillomavirus (HPV) test (<it>care</it>HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia.</p> <p>Methods</p> <p>We assessed the outcomes and cost-effectiveness of <it>care</it>HPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed.</p> <p>Results</p> <p>For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; <it>care</it>HPV@1.0 pg/ml and <it>care</it>HPV@0.5 pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for <it>care</it>HPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for <it>care</it>HPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using <it>care</it>HPV@1.0) per LYS.</p> <p>Conclusions</p> <p>This modelled analysis suggests that primary <it>care</it>HPV screening compares favourably to visual inspection screening methodologies in rural China, particularly if used as part of a regular screening program.</p> http://www.biomedcentral.com/1471-2407/11/239 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kang Yoon-Jung Ma Li Simonella Leonardo Ning Yan Legood Rosa Zhao Fang-Hui Lew Jie-Bin Canfell Karen Shi Ju-Fang Zhang Yong-Zhen Smith Megan A Chen Jun-Feng Feng Xiang-Xian Qiao You-Lin |
spellingShingle |
Kang Yoon-Jung Ma Li Simonella Leonardo Ning Yan Legood Rosa Zhao Fang-Hui Lew Jie-Bin Canfell Karen Shi Ju-Fang Zhang Yong-Zhen Smith Megan A Chen Jun-Feng Feng Xiang-Xian Qiao You-Lin Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study BMC Cancer |
author_facet |
Kang Yoon-Jung Ma Li Simonella Leonardo Ning Yan Legood Rosa Zhao Fang-Hui Lew Jie-Bin Canfell Karen Shi Ju-Fang Zhang Yong-Zhen Smith Megan A Chen Jun-Feng Feng Xiang-Xian Qiao You-Lin |
author_sort |
Kang Yoon-Jung |
title |
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study |
title_short |
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study |
title_full |
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study |
title_fullStr |
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study |
title_full_unstemmed |
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study |
title_sort |
evaluation of primary hpv-dna testing in relation to visual inspection methods for cervical cancer screening in rural china: an epidemiologic and cost-effectiveness modelling study |
publisher |
BMC |
series |
BMC Cancer |
issn |
1471-2407 |
publishDate |
2011-06-01 |
description |
<p>Abstract</p> <p>Background</p> <p>A new lower-cost rapid-throughput human papillomavirus (HPV) test (<it>care</it>HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia.</p> <p>Methods</p> <p>We assessed the outcomes and cost-effectiveness of <it>care</it>HPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed.</p> <p>Results</p> <p>For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA/VILI; <it>care</it>HPV@1.0 pg/ml and <it>care</it>HPV@0.5 pg/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for <it>care</it>HPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for <it>care</it>HPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using <it>care</it>HPV@1.0) per LYS.</p> <p>Conclusions</p> <p>This modelled analysis suggests that primary <it>care</it>HPV screening compares favourably to visual inspection screening methodologies in rural China, particularly if used as part of a regular screening program.</p> |
url |
http://www.biomedcentral.com/1471-2407/11/239 |
work_keys_str_mv |
AT kangyoonjung evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT mali evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT simonellaleonardo evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT ningyan evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT legoodrosa evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT zhaofanghui evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT lewjiebin evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT canfellkaren evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT shijufang evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT zhangyongzhen evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT smithmegana evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT chenjunfeng evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT fengxiangxian evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy AT qiaoyoulin evaluationofprimaryhpvdnatestinginrelationtovisualinspectionmethodsforcervicalcancerscreeninginruralchinaanepidemiologicandcosteffectivenessmodellingstudy |
_version_ |
1725550809390776320 |