Resolvin D1 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Increasing Treg Percentages via the ALX/FPR2 Pathway

Resolvin D1 Protects Against Ischemia/Reperfusion-Induced Acute Kidney Injury by Increasing Treg Percentages via the ALX/FPR2 Pathway

AimsTo evaluate whether Resolvin D1 attenuates ischemia/reperfusion-induced (IRI) acute kidney injury (AKI) via affecting Tregs.Materials and MethodsThe IRI-AKI mouse model was established, and RvD1 was injected into the mouse tail vein. Further, the renal function, histological changes, injury mark...

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Bibliographic Details
Main Authors: Hong Luan, Chuanxiao Wang, Jianping Sun, Long Zhao, Lin Li, Bin Zhou, Shihong Shao, Xuefei Shen, Yan Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Physiology
Subjects:
acute kidney injury
Resolvin D1
regulatory T cells
ischemia-reperfusion injury
LXA4 receptor
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00285/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00285/full

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