Antibiotic exposure and growth patterns in preterm, very low birth weight infants
Abstract Background Antibiotic exposure in term infants has been associated with later obesity. Premature, very-low-birth-weight (birth weight ≤ 1500 g) infants in the neonatal intensive care unit frequently are exposed to antibiotics. Our hypothesis was that in preterm infants, there is a positive...
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doaj-671dd503a04f4ea1b453302a721360d22021-01-31T16:17:43ZengBMCMaternal Health, Neonatology and Perinatology2054-958X2021-01-01711810.1186/s40748-021-00126-6Antibiotic exposure and growth patterns in preterm, very low birth weight infantsAlaina K. Pyle0Joseph B. Cantey1L. Steven Brown2Roy J. Heyne3Phillip S. Wozniak4Elizabeth Heyne5Amy Holcombe6Elizabeth M. Brammer7Cheryl S. Lair8Pablo J. Sánchez9Department of Pediatrics, University of Texas Southwestern Medical CenterDepartment of Pediatrics, University of Texas Southwestern Medical CenterHealth System Research, Parkland Health and Hospital SystemDepartment of Pediatrics, University of Texas Southwestern Medical CenterDepartment of Pediatrics, University of Texas Southwestern Medical CenterChildren’s Medical CenterChildren’s Medical CenterNutrition Services, Parkland Health and Hospital SystemNutrition Services, Parkland Health and Hospital SystemDepartment of Pediatrics, University of Texas Southwestern Medical CenterAbstract Background Antibiotic exposure in term infants has been associated with later obesity. Premature, very-low-birth-weight (birth weight ≤ 1500 g) infants in the neonatal intensive care unit frequently are exposed to antibiotics. Our hypothesis was that in preterm infants, there is a positive linear and dose-dependent relationship between antibiotic exposure and growth from birth through 12 months’ corrected age. Methods Retrospective analysis of prospectively collected data of all antibiotic use among inborn, preterm (≤32 weeks’ gestation), very-low-birth-weight infants admitted to the neonatal intensive care unit at Parkland Memorial Hospital and followed in the Low Birth Weight Clinic at Children’s Medical Center, Dallas, TX. Antibiotic use was quantified by days of therapy which was compared with weight and length parameters at birth, 36 weeks’ postmenstrual age, and 2, 4, 6, and 12 months’ corrected age. The change in weight and length z-scores from birth to all subsequent age points was calculated. Stepwise multivariate regression analysis was performed to determine predictors of weight, length, and weight-for-length delta z-scores from birth to each subsequent age point. Results During the 18-month study, 161 infants received a median of 11 (IQR, 5.5–19.5) antibiotic days of therapy which was not associated with weight or length delta z-scores from birth through 12 months’ corrected age. Conclusion Association of prolonged antibiotic use and neonatal morbidities and mortality may override the potential association with increased weight gain in the NICU and beyond.https://doi.org/10.1186/s40748-021-00126-6Very low birth weightNeonateAntibioticObesityStewardship |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alaina K. Pyle Joseph B. Cantey L. Steven Brown Roy J. Heyne Phillip S. Wozniak Elizabeth Heyne Amy Holcombe Elizabeth M. Brammer Cheryl S. Lair Pablo J. Sánchez |
spellingShingle |
Alaina K. Pyle Joseph B. Cantey L. Steven Brown Roy J. Heyne Phillip S. Wozniak Elizabeth Heyne Amy Holcombe Elizabeth M. Brammer Cheryl S. Lair Pablo J. Sánchez Antibiotic exposure and growth patterns in preterm, very low birth weight infants Maternal Health, Neonatology and Perinatology Very low birth weight Neonate Antibiotic Obesity Stewardship |
author_facet |
Alaina K. Pyle Joseph B. Cantey L. Steven Brown Roy J. Heyne Phillip S. Wozniak Elizabeth Heyne Amy Holcombe Elizabeth M. Brammer Cheryl S. Lair Pablo J. Sánchez |
author_sort |
Alaina K. Pyle |
title |
Antibiotic exposure and growth patterns in preterm, very low birth weight infants |
title_short |
Antibiotic exposure and growth patterns in preterm, very low birth weight infants |
title_full |
Antibiotic exposure and growth patterns in preterm, very low birth weight infants |
title_fullStr |
Antibiotic exposure and growth patterns in preterm, very low birth weight infants |
title_full_unstemmed |
Antibiotic exposure and growth patterns in preterm, very low birth weight infants |
title_sort |
antibiotic exposure and growth patterns in preterm, very low birth weight infants |
publisher |
BMC |
series |
Maternal Health, Neonatology and Perinatology |
issn |
2054-958X |
publishDate |
2021-01-01 |
description |
Abstract Background Antibiotic exposure in term infants has been associated with later obesity. Premature, very-low-birth-weight (birth weight ≤ 1500 g) infants in the neonatal intensive care unit frequently are exposed to antibiotics. Our hypothesis was that in preterm infants, there is a positive linear and dose-dependent relationship between antibiotic exposure and growth from birth through 12 months’ corrected age. Methods Retrospective analysis of prospectively collected data of all antibiotic use among inborn, preterm (≤32 weeks’ gestation), very-low-birth-weight infants admitted to the neonatal intensive care unit at Parkland Memorial Hospital and followed in the Low Birth Weight Clinic at Children’s Medical Center, Dallas, TX. Antibiotic use was quantified by days of therapy which was compared with weight and length parameters at birth, 36 weeks’ postmenstrual age, and 2, 4, 6, and 12 months’ corrected age. The change in weight and length z-scores from birth to all subsequent age points was calculated. Stepwise multivariate regression analysis was performed to determine predictors of weight, length, and weight-for-length delta z-scores from birth to each subsequent age point. Results During the 18-month study, 161 infants received a median of 11 (IQR, 5.5–19.5) antibiotic days of therapy which was not associated with weight or length delta z-scores from birth through 12 months’ corrected age. Conclusion Association of prolonged antibiotic use and neonatal morbidities and mortality may override the potential association with increased weight gain in the NICU and beyond. |
topic |
Very low birth weight Neonate Antibiotic Obesity Stewardship |
url |
https://doi.org/10.1186/s40748-021-00126-6 |
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