DNA methylation at enhancers identifies distinct breast cancer lineages

DNA methylation at enhancers identifies distinct breast cancer lineages

Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers ab...

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Main Authors: Thomas Fleischer, Xavier Tekpli, Anthony Mathelier, Shixiong Wang, Daniel Nebdal, Hari P. Dhakal, Kristine Kleivi Sahlberg, Ellen Schlichting, Oslo Breast Cancer Research Consortium (OSBREAC), Anne-Lise Børresen-Dale, Elin Borgen, Bjørn Naume, Ragnhild Eskeland, Arnoldo Frigessi, Jörg Tost, Antoni Hurtado, Vessela N. Kristensen
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00510-x
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spelling doaj-672c1ec295c94bbb9950c3781c1429a72021-05-11T07:03:31ZengNature Publishing GroupNature Communications2041-17232017-11-018111410.1038/s41467-017-00510-xDNA methylation at enhancers identifies distinct breast cancer lineagesThomas Fleischer0Xavier Tekpli1Anthony Mathelier2Shixiong Wang3Daniel Nebdal4Hari P. Dhakal5Kristine Kleivi Sahlberg6Ellen Schlichting7Oslo Breast Cancer Research Consortium (OSBREAC)Anne-Lise Børresen-Dale8Elin Borgen9Bjørn Naume10Ragnhild Eskeland11Arnoldo Frigessi12Jörg Tost13Antoni Hurtado14Vessela N. Kristensen15Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalCentre for Molecular Medicine Norway (NCMM), University of OsloDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Pathology, Oslo University HospitalDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Oncology, Oslo University HospitalDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Pathology, Oslo University HospitalDepartment of Oncology, Oslo University HospitalDepartment of Biosciences, University of OsloDepartment of Biostatistics, Oslo Centre for Biostatistics and Epidemiology, University of Oslo and Research Support Services, Oslo University HospitalLaboratory for Epigenetics and Environment, Centre National de Génotypage, CEA–Institut de GénomiqueDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalDepartment of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium HospitalBreast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.https://doi.org/10.1038/s41467-017-00510-x
collection DOAJ
language English
format Article
sources DOAJ
author Thomas Fleischer
Xavier Tekpli
Anthony Mathelier
Shixiong Wang
Daniel Nebdal
Hari P. Dhakal
Kristine Kleivi Sahlberg
Ellen Schlichting
Oslo Breast Cancer Research Consortium (OSBREAC)
Anne-Lise Børresen-Dale
Elin Borgen
Bjørn Naume
Ragnhild Eskeland
Arnoldo Frigessi
Jörg Tost
Antoni Hurtado
Vessela N. Kristensen
spellingShingle Thomas Fleischer
Xavier Tekpli
Anthony Mathelier
Shixiong Wang
Daniel Nebdal
Hari P. Dhakal
Kristine Kleivi Sahlberg
Ellen Schlichting
Oslo Breast Cancer Research Consortium (OSBREAC)
Anne-Lise Børresen-Dale
Elin Borgen
Bjørn Naume
Ragnhild Eskeland
Arnoldo Frigessi
Jörg Tost
Antoni Hurtado
Vessela N. Kristensen
DNA methylation at enhancers identifies distinct breast cancer lineages
Nature Communications
author_facet Thomas Fleischer
Xavier Tekpli
Anthony Mathelier
Shixiong Wang
Daniel Nebdal
Hari P. Dhakal
Kristine Kleivi Sahlberg
Ellen Schlichting
Oslo Breast Cancer Research Consortium (OSBREAC)
Anne-Lise Børresen-Dale
Elin Borgen
Bjørn Naume
Ragnhild Eskeland
Arnoldo Frigessi
Jörg Tost
Antoni Hurtado
Vessela N. Kristensen
author_sort Thomas Fleischer
title DNA methylation at enhancers identifies distinct breast cancer lineages
title_short DNA methylation at enhancers identifies distinct breast cancer lineages
title_full DNA methylation at enhancers identifies distinct breast cancer lineages
title_fullStr DNA methylation at enhancers identifies distinct breast cancer lineages
title_full_unstemmed DNA methylation at enhancers identifies distinct breast cancer lineages
title_sort dna methylation at enhancers identifies distinct breast cancer lineages
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Breast cancers are classified based on gene expression profiles but it is well known that DNA methylation patterns are also altered. Here the authors, by combining genome-wide DNA methylation and gene expression analysis, identify transcriptional networks regulated by DNA methylation at enhancers able to separate specific breast cancer subtypes.
url https://doi.org/10.1038/s41467-017-00510-x
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