XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis
Lung cancer is the most frequently diagnosed cancer and the main cause of cancer death in the world. X-box binding protein 1 (XBP1), which is an important transcription factor involved in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, might act as a potent o...
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Format: | Article |
Language: | English |
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Frontiers Media S.A.
2021-05-01
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Series: | Frontiers in Oncology |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.654995/full |
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doaj-6730eca1755c459bb241240ce4ce40be |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qingxi Luo Qingxi Luo Wenwen Shi Bo Dou Jun Wang Wei Peng Xianyu Liu Deze Zhao Faqing Tang Yingfang Wu Xizhe Li Jiajia Li Siqi Wen Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang Chaojun Duan Chaojun Duan Chaojun Duan Chaojun Duan |
spellingShingle |
Qingxi Luo Qingxi Luo Wenwen Shi Bo Dou Jun Wang Wei Peng Xianyu Liu Deze Zhao Faqing Tang Yingfang Wu Xizhe Li Jiajia Li Siqi Wen Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang Chaojun Duan Chaojun Duan Chaojun Duan Chaojun Duan XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis Frontiers in Oncology NSCLC XBP1 IGFBP3 invasion metastasis |
author_facet |
Qingxi Luo Qingxi Luo Wenwen Shi Bo Dou Jun Wang Wei Peng Xianyu Liu Deze Zhao Faqing Tang Yingfang Wu Xizhe Li Jiajia Li Siqi Wen Chunfang Zhang Chunfang Zhang Chunfang Zhang Chunfang Zhang Chaojun Duan Chaojun Duan Chaojun Duan Chaojun Duan |
author_sort |
Qingxi Luo |
title |
XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis |
title_short |
XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis |
title_full |
XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis |
title_fullStr |
XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis |
title_full_unstemmed |
XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and Metastasis |
title_sort |
xbp1- igfbp3 signaling pathway promotes nsclc invasion and metastasis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2021-05-01 |
description |
Lung cancer is the most frequently diagnosed cancer and the main cause of cancer death in the world. X-box binding protein 1 (XBP1), which is an important transcription factor involved in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, might act as a potent oncogenic protein in the processes of tumorigenesis, tumor proliferation and metastasis in various cancers. However, the clinical significance and pathological role of XBP1 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we investigated the expression of XBP1s protein in the 104 NSCLC tumor tissues and matched adjacent normal lung tissues (ANLT) by Immunohistochemical (IHC), and we found overexpressed XBP1s protein was associated with NSCLC TNM stages, lymph node metastasis and poor prognosis. The further gain-and loss-of-function experiments indicated overexpression of XBP1s protein promoted cell invasion, migration and metastasis both in vitro and in vivo. Further study showed XBP1s protein could upregulate insulin-like growth factor binding protein-3 (IGFBP3) expression, and regulated NSCLC cells invasion and metastasis by regulating IGFBP3. Taken together, XBP1s protein is markedly overexpressed in NSCLC and serves as an oncogene that play a critical role in NSCLC tumorigenesis and development. Importantly, XBP1s protein might not only be a potential biomarker for metastasis and prognosis but also a potential therapeutic target in NSCLC. |
topic |
NSCLC XBP1 IGFBP3 invasion metastasis |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2021.654995/full |
work_keys_str_mv |
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doaj-6730eca1755c459bb241240ce4ce40be2021-05-18T15:19:29ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-05-011110.3389/fonc.2021.654995654995XBP1- IGFBP3 Signaling Pathway Promotes NSCLC Invasion and MetastasisQingxi Luo0Qingxi Luo1Wenwen Shi2Bo Dou3Jun Wang4Wei Peng5Xianyu Liu6Deze Zhao7Faqing Tang8Yingfang Wu9Xizhe Li10Jiajia Li11Siqi Wen12Chunfang Zhang13Chunfang Zhang14Chunfang Zhang15Chunfang Zhang16Chaojun Duan17Chaojun Duan18Chaojun Duan19Chaojun Duan20Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Oncology, Hunan Provincial People’s Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Oncotarget Gene, Department of Clinical Laboratory, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, ChinaCentre of Stomatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, ChinaHunan Engineering Research Center for Pulmonary Nodules Precise Diagnosis & Treatment Xiangya Hospital, Central South University, Changsha, ChinaInstitute of Medical Sciences, Xiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaLung cancer is the most frequently diagnosed cancer and the main cause of cancer death in the world. X-box binding protein 1 (XBP1), which is an important transcription factor involved in regulating the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress, might act as a potent oncogenic protein in the processes of tumorigenesis, tumor proliferation and metastasis in various cancers. However, the clinical significance and pathological role of XBP1 in non-small cell lung cancer (NSCLC) remains unknown. In this study, we investigated the expression of XBP1s protein in the 104 NSCLC tumor tissues and matched adjacent normal lung tissues (ANLT) by Immunohistochemical (IHC), and we found overexpressed XBP1s protein was associated with NSCLC TNM stages, lymph node metastasis and poor prognosis. The further gain-and loss-of-function experiments indicated overexpression of XBP1s protein promoted cell invasion, migration and metastasis both in vitro and in vivo. Further study showed XBP1s protein could upregulate insulin-like growth factor binding protein-3 (IGFBP3) expression, and regulated NSCLC cells invasion and metastasis by regulating IGFBP3. Taken together, XBP1s protein is markedly overexpressed in NSCLC and serves as an oncogene that play a critical role in NSCLC tumorigenesis and development. Importantly, XBP1s protein might not only be a potential biomarker for metastasis and prognosis but also a potential therapeutic target in NSCLC.https://www.frontiersin.org/articles/10.3389/fonc.2021.654995/fullNSCLCXBP1IGFBP3invasionmetastasis |