Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012.
Streptococcus pneumoniae is a leading cause of pneumonia worldwide. However, the burden of pneumococcal pneumonia among adults in low- and middle-income countries is not well described.Data from 2008-2012 was analyzed from two surveillance sites in Guatemala to describe the incidence of pneumococcal...
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doaj-6734d3307b314472baf214f4a5ccc5142020-11-24T20:45:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011010e014093910.1371/journal.pone.0140939Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012.Carmen Lucía ContrerasJennifer R VeraniMaría Renee LopezAntonio ParedesChris BernartFabiola MoscosoAleida RoldanWences ArveloKim A LindbladeJohn P McCrackenStreptococcus pneumoniae is a leading cause of pneumonia worldwide. However, the burden of pneumococcal pneumonia among adults in low- and middle-income countries is not well described.Data from 2008-2012 was analyzed from two surveillance sites in Guatemala to describe the incidence of pneumococcal pneumonia in adults. A case of hospitalized pneumococcal pneumonia was defined as a positive pneumococcal urinary antigen test or blood culture in persons aged ≥ 18 years hospitalized with an acute respiratory infection (ARI).Among 1595 adults admitted with ARI, 1363 (82%) had either urine testing (n = 1286) or blood culture (n = 338) performed. Of these, 188 (14%) had pneumococcal pneumonia, including 173 detected by urine only, 8 by blood culture only, and 7 by both methods. Incidence rates increased with age, with the lowest rate among 18-24 year-olds (2.75/100,000) and the highest among ≥65 year-olds (31.3/100,000). The adjusted incidence of hospitalized pneumococcal pneumonia was 18.6/100,000 overall, with in-hospital mortality of 5%.An important burden of hospitalized pneumococcal pneumonia in adults was described, particularly for the elderly. However, even adjusted rates likely underestimate the true burden of pneumococcal pneumonia in the community. These data provide a baseline against which to measure the indirect effects of the 2013 introduction of the pneumococcal conjugate vaccine in children in Guatemala.http://europepmc.org/articles/PMC4619266?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Carmen Lucía Contreras Jennifer R Verani María Renee Lopez Antonio Paredes Chris Bernart Fabiola Moscoso Aleida Roldan Wences Arvelo Kim A Lindblade John P McCracken |
spellingShingle |
Carmen Lucía Contreras Jennifer R Verani María Renee Lopez Antonio Paredes Chris Bernart Fabiola Moscoso Aleida Roldan Wences Arvelo Kim A Lindblade John P McCracken Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. PLoS ONE |
author_facet |
Carmen Lucía Contreras Jennifer R Verani María Renee Lopez Antonio Paredes Chris Bernart Fabiola Moscoso Aleida Roldan Wences Arvelo Kim A Lindblade John P McCracken |
author_sort |
Carmen Lucía Contreras |
title |
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. |
title_short |
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. |
title_full |
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. |
title_fullStr |
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. |
title_full_unstemmed |
Incidence of Hospitalized Pneumococcal Pneumonia among Adults in Guatemala, 2008-2012. |
title_sort |
incidence of hospitalized pneumococcal pneumonia among adults in guatemala, 2008-2012. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2015-01-01 |
description |
Streptococcus pneumoniae is a leading cause of pneumonia worldwide. However, the burden of pneumococcal pneumonia among adults in low- and middle-income countries is not well described.Data from 2008-2012 was analyzed from two surveillance sites in Guatemala to describe the incidence of pneumococcal pneumonia in adults. A case of hospitalized pneumococcal pneumonia was defined as a positive pneumococcal urinary antigen test or blood culture in persons aged ≥ 18 years hospitalized with an acute respiratory infection (ARI).Among 1595 adults admitted with ARI, 1363 (82%) had either urine testing (n = 1286) or blood culture (n = 338) performed. Of these, 188 (14%) had pneumococcal pneumonia, including 173 detected by urine only, 8 by blood culture only, and 7 by both methods. Incidence rates increased with age, with the lowest rate among 18-24 year-olds (2.75/100,000) and the highest among ≥65 year-olds (31.3/100,000). The adjusted incidence of hospitalized pneumococcal pneumonia was 18.6/100,000 overall, with in-hospital mortality of 5%.An important burden of hospitalized pneumococcal pneumonia in adults was described, particularly for the elderly. However, even adjusted rates likely underestimate the true burden of pneumococcal pneumonia in the community. These data provide a baseline against which to measure the indirect effects of the 2013 introduction of the pneumococcal conjugate vaccine in children in Guatemala. |
url |
http://europepmc.org/articles/PMC4619266?pdf=render |
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