Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers
Abstract Background Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention. Methods The anticancer effects of three essential oils from the...
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doaj-67398f568cd94af098887d04ba424fe12021-07-04T11:49:28ZengBMCBMC Complementary Medicine and Therapies2662-76712021-07-0121111010.1186/s12906-021-03362-7Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancersHiva Alipanah0Mojtaba Farjam1Elham Zarenezhad2Ghazaal Roozitalab3Mahmoud Osanloo4Department of Physiology, School of Medicine, Fasa University of Medical SciencesNoncommunicable Diseases Research Center, Fasa University of Medical SciencesNoncommunicable Diseases Research Center, Fasa University of Medical SciencesNoncommunicable Diseases Research Center, Fasa University of Medical SciencesDepartment of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical SciencesAbstract Background Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention. Methods The anticancer effects of three essential oils from the Citrus family and their identified major constituents (limonene) were first investigated against melanoma and breast cancer cell lines (A-375 and MDA-MB-468). By preparing chitosan nanoparticles containing them, an attempt was then made to improve their effectiveness. Results Chitosan nanoparticles containing Citrus sinensis and Citrus limon essential oils with IC50s of 0.03 and 0.124 μg/mL on A-375 cells, and 23.65 and 40.32 μg/mL on MDA-MB-468 showed distinct anticancer efficacies. Conclusion The prepared formulations could thus be considered as green anticancer agents in complementary medicine and therapies.https://doi.org/10.1186/s12906-021-03362-7CitrusTriple negative breast neoplasmsSkin neoplasmsPhytochemicalsCytostatic agents |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiva Alipanah Mojtaba Farjam Elham Zarenezhad Ghazaal Roozitalab Mahmoud Osanloo |
spellingShingle |
Hiva Alipanah Mojtaba Farjam Elham Zarenezhad Ghazaal Roozitalab Mahmoud Osanloo Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers BMC Complementary Medicine and Therapies Citrus Triple negative breast neoplasms Skin neoplasms Phytochemicals Cytostatic agents |
author_facet |
Hiva Alipanah Mojtaba Farjam Elham Zarenezhad Ghazaal Roozitalab Mahmoud Osanloo |
author_sort |
Hiva Alipanah |
title |
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
title_short |
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
title_full |
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
title_fullStr |
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
title_full_unstemmed |
Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
title_sort |
chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers |
publisher |
BMC |
series |
BMC Complementary Medicine and Therapies |
issn |
2662-7671 |
publishDate |
2021-07-01 |
description |
Abstract Background Melanoma and breast cancers are two common cancers worldwide. Due to the side effects of chemotherapy drugs and the occurring resistance against them, the development of green drugs has been received more attention. Methods The anticancer effects of three essential oils from the Citrus family and their identified major constituents (limonene) were first investigated against melanoma and breast cancer cell lines (A-375 and MDA-MB-468). By preparing chitosan nanoparticles containing them, an attempt was then made to improve their effectiveness. Results Chitosan nanoparticles containing Citrus sinensis and Citrus limon essential oils with IC50s of 0.03 and 0.124 μg/mL on A-375 cells, and 23.65 and 40.32 μg/mL on MDA-MB-468 showed distinct anticancer efficacies. Conclusion The prepared formulations could thus be considered as green anticancer agents in complementary medicine and therapies. |
topic |
Citrus Triple negative breast neoplasms Skin neoplasms Phytochemicals Cytostatic agents |
url |
https://doi.org/10.1186/s12906-021-03362-7 |
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