Mutation bias and GC content shape antimutator invasions
Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-11217-6 |
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doaj-67417fa7d81b4f77964910427aefd29a |
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Article |
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doaj-67417fa7d81b4f77964910427aefd29a2021-05-11T11:40:32ZengNature Publishing GroupNature Communications2041-17232019-07-011011910.1038/s41467-019-11217-6Mutation bias and GC content shape antimutator invasionsAlejandro Couce0Olivier Tenaillon1Unité Mixte de Recherche 1137 (IAME-INSERM), Université Paris DiderotUnité Mixte de Recherche 1137 (IAME-INSERM), Université Paris DiderotMutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics.https://doi.org/10.1038/s41467-019-11217-6 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Alejandro Couce Olivier Tenaillon |
| spellingShingle |
Alejandro Couce Olivier Tenaillon Mutation bias and GC content shape antimutator invasions Nature Communications |
| author_facet |
Alejandro Couce Olivier Tenaillon |
| author_sort |
Alejandro Couce |
| title |
Mutation bias and GC content shape antimutator invasions |
| title_short |
Mutation bias and GC content shape antimutator invasions |
| title_full |
Mutation bias and GC content shape antimutator invasions |
| title_fullStr |
Mutation bias and GC content shape antimutator invasions |
| title_full_unstemmed |
Mutation bias and GC content shape antimutator invasions |
| title_sort |
mutation bias and gc content shape antimutator invasions |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-07-01 |
| description |
Mutators are expected to re-evolve low mutation rates to reduce deleterious load, but empirical evidence is mixed. Here, the authors show that load can vary across mutators and genetic backgrounds, which their simulations suggest can substantially alter antimutator dynamics. |
| url |
https://doi.org/10.1038/s41467-019-11217-6 |
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AT alejandrocouce mutationbiasandgccontentshapeantimutatorinvasions AT oliviertenaillon mutationbiasandgccontentshapeantimutatorinvasions |
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