Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy
Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MN...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2018-11-01
|
Series: | Medical Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3271/6/4/105 |
id |
doaj-675974b50d1e4741938a12b34d1fbb71 |
---|---|
record_format |
Article |
spelling |
doaj-675974b50d1e4741938a12b34d1fbb712020-11-24T21:34:04ZengMDPI AGMedical Sciences2076-32712018-11-016410510.3390/medsci6040105medsci6040105Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during MalignancyGohar Hakobyan0Hasmik Davtyan1Kristine Harutyunyan2Knarik Alexanyan3Yelizaveta Amirkhanyan4Anna L. Gharibyan5Liana Asatryan6Yuri Tadevosyan7Laboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, ArmeniaLaboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, ArmeniaLaboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, ArmeniaCenter of Oncology after V. Fanarjyan, Ministry of Health RA, 0052 Yerevan, ArmeniaCenter of Hematology after R. Yeolyan, Ministry of Health RA, 0014 Yerevan, ArmeniaDepartment of Medical Biochemistry and Biophysics, Umeå University, SE-901 87 Umeå, SwedenSchool of Pharmacy, University of Southern California, Los Angeles, CA 90033, USALaboratory of Regulation of Cellular Activity, Institute of Molecular Biology, National Academy of Sciences, 0014 Yerevan, ArmeniaPhospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MNCs) play an important role in antitumor immune response by reacting to cancerous modifications in distant organs. In the current study, we tested the hypothesis that tumor initiation and development are reflected in the alteration pattern of the MNC PL component. We analyzed MNC membrane PL fractions in samples from healthy individuals and from patients with diverse types of cancers to reveal possible alterations induced by malignancy. Compared to healthy controls, the cancer samples demonstrated shifts in several membrane PL profiles. In particular, when analyzing cancer data pooled together, there were significantly higher levels in lysophosphatidylcholine, phosphatidylcholine, and phosphatidylethanolamine fractions, and significantly lower quantities in phosphatidylinositol, phosphatidylserine, and phosphatidic acid fractions in cancer samples compared to controls. The levels of sphingomyelins and diphosphatidylglycerols were relatively unaffected. Most of the differences in PLs were sustained during the analysis of individual cancers such as breast cancer and chronic lymphocytic leukemia. Our findings suggest the presence of a common pattern of changes in MNC PLs during malignancy.https://www.mdpi.com/2076-3271/6/4/105cancersmononuclear cellsplasma membranephospholipidsbiomarkers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gohar Hakobyan Hasmik Davtyan Kristine Harutyunyan Knarik Alexanyan Yelizaveta Amirkhanyan Anna L. Gharibyan Liana Asatryan Yuri Tadevosyan |
spellingShingle |
Gohar Hakobyan Hasmik Davtyan Kristine Harutyunyan Knarik Alexanyan Yelizaveta Amirkhanyan Anna L. Gharibyan Liana Asatryan Yuri Tadevosyan Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy Medical Sciences cancers mononuclear cells plasma membrane phospholipids biomarkers |
author_facet |
Gohar Hakobyan Hasmik Davtyan Kristine Harutyunyan Knarik Alexanyan Yelizaveta Amirkhanyan Anna L. Gharibyan Liana Asatryan Yuri Tadevosyan |
author_sort |
Gohar Hakobyan |
title |
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy |
title_short |
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy |
title_full |
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy |
title_fullStr |
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy |
title_full_unstemmed |
Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles during Malignancy |
title_sort |
similarities in blood mononuclear cell membrane phospholipid profiles during malignancy |
publisher |
MDPI AG |
series |
Medical Sciences |
issn |
2076-3271 |
publishDate |
2018-11-01 |
description |
Phospholipids (PLs), key elements of cellular membranes, are regulated reciprocally with membrane proteins and can act as sensors for alterations in physiological or pathological states of cells including initiation and development of cancer. On the other hand, peripheral blood mononuclear cells (MNCs) play an important role in antitumor immune response by reacting to cancerous modifications in distant organs. In the current study, we tested the hypothesis that tumor initiation and development are reflected in the alteration pattern of the MNC PL component. We analyzed MNC membrane PL fractions in samples from healthy individuals and from patients with diverse types of cancers to reveal possible alterations induced by malignancy. Compared to healthy controls, the cancer samples demonstrated shifts in several membrane PL profiles. In particular, when analyzing cancer data pooled together, there were significantly higher levels in lysophosphatidylcholine, phosphatidylcholine, and phosphatidylethanolamine fractions, and significantly lower quantities in phosphatidylinositol, phosphatidylserine, and phosphatidic acid fractions in cancer samples compared to controls. The levels of sphingomyelins and diphosphatidylglycerols were relatively unaffected. Most of the differences in PLs were sustained during the analysis of individual cancers such as breast cancer and chronic lymphocytic leukemia. Our findings suggest the presence of a common pattern of changes in MNC PLs during malignancy. |
topic |
cancers mononuclear cells plasma membrane phospholipids biomarkers |
url |
https://www.mdpi.com/2076-3271/6/4/105 |
work_keys_str_mv |
AT goharhakobyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT hasmikdavtyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT kristineharutyunyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT knarikalexanyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT yelizavetaamirkhanyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT annalgharibyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT lianaasatryan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy AT yuritadevosyan similaritiesinbloodmononuclearcellmembranephospholipidprofilesduringmalignancy |
_version_ |
1725950655014633472 |