Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women
<i>Background and Objectives</i>: Recent studies have shown that low skeletal muscle mass can contribute to non-alcoholic fatty liver disease through insulin resistance. However, the association between muscle mass/strength and hepatic fat content remains unclear in postmenopausal women....
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doaj-675afb1e6e704aaa8f8027eabcb2b0652020-11-25T02:10:07ZengMDPI AGMedicina1010-660X2019-09-01551062910.3390/medicina55100629medicina55100629Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal WomenYajie Zhang0Dajiang Lu1Renwei Wang2Weijie Fu3Shengnian Zhang4School of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, ChinaSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China<i>Background and Objectives</i>: Recent studies have shown that low skeletal muscle mass can contribute to non-alcoholic fatty liver disease through insulin resistance. However, the association between muscle mass/strength and hepatic fat content remains unclear in postmenopausal women. <i>Methods</i>: In this study, we assessed the associations between muscle mass/strength and various severities of non-alcoholic fatty liver disease. Using single-voxel proton magnetic resonance spectroscopy, 96 postmenopausal women between the ages of 50 and 65 were divided into four groups (G0−G3) by hepatic fat content: G0 (hepatic fat content <5%, <i>n</i> = 20), G1 (5% ≤ hepatic fat content < 10%, <i>n</i> = 27), G2 (10% ≤ hepatic fat content < 25%, <i>n</i> = 31), and G3 (hepatic fat content ≥25%, <i>n</i> = 18). Muscle mass indexes were estimated as skeletal muscle index (SMI)% (total lean mass/weight × 100) and appendicular skeletal muscular mass index (ASM)% (appendicular lean mass/weight × 100) by dual energy X-ray absorptiometry. Maximal isometric voluntary contraction of the handgrip, elbow flexors, and knee extensors was measured using an adjustable dynamometer chair. Fasting plasma glucose, insulin, and follicle-stimulating hormones were assessed in venous blood samples. <i>Results</i>: The results showed negative correlations between hepatic fat content and SMI% (r = −0.42, <i>p</i> < 0.001), ASM% (r = −0.29, <i>p</i> = 0.005), maximal voluntary force of grip (r = −0.22, <i>p</i> = 0.037), and knee extensors (r = −0.22, <i>p</i> = 0.032). <i>Conclusions</i>: These significant correlations almost remained unchanged even after controlling for insulin resistance. In conclusion, negative correlations exist between muscle mass/strength and the progressed severity of non-alcoholic fatty liver disease among post-menopausal women, and the correlations are independent of insulin resistance.https://www.mdpi.com/1010-660X/55/10/629grip strengthknee extensorssarcopeniamiddle-aged women |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yajie Zhang Dajiang Lu Renwei Wang Weijie Fu Shengnian Zhang |
spellingShingle |
Yajie Zhang Dajiang Lu Renwei Wang Weijie Fu Shengnian Zhang Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women Medicina grip strength knee extensors sarcopenia middle-aged women |
author_facet |
Yajie Zhang Dajiang Lu Renwei Wang Weijie Fu Shengnian Zhang |
author_sort |
Yajie Zhang |
title |
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women |
title_short |
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women |
title_full |
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women |
title_fullStr |
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women |
title_full_unstemmed |
Relationship between Muscle Mass/Strength and Hepatic Fat Content in Post-Menopausal Women |
title_sort |
relationship between muscle mass/strength and hepatic fat content in post-menopausal women |
publisher |
MDPI AG |
series |
Medicina |
issn |
1010-660X |
publishDate |
2019-09-01 |
description |
<i>Background and Objectives</i>: Recent studies have shown that low skeletal muscle mass can contribute to non-alcoholic fatty liver disease through insulin resistance. However, the association between muscle mass/strength and hepatic fat content remains unclear in postmenopausal women. <i>Methods</i>: In this study, we assessed the associations between muscle mass/strength and various severities of non-alcoholic fatty liver disease. Using single-voxel proton magnetic resonance spectroscopy, 96 postmenopausal women between the ages of 50 and 65 were divided into four groups (G0−G3) by hepatic fat content: G0 (hepatic fat content <5%, <i>n</i> = 20), G1 (5% ≤ hepatic fat content < 10%, <i>n</i> = 27), G2 (10% ≤ hepatic fat content < 25%, <i>n</i> = 31), and G3 (hepatic fat content ≥25%, <i>n</i> = 18). Muscle mass indexes were estimated as skeletal muscle index (SMI)% (total lean mass/weight × 100) and appendicular skeletal muscular mass index (ASM)% (appendicular lean mass/weight × 100) by dual energy X-ray absorptiometry. Maximal isometric voluntary contraction of the handgrip, elbow flexors, and knee extensors was measured using an adjustable dynamometer chair. Fasting plasma glucose, insulin, and follicle-stimulating hormones were assessed in venous blood samples. <i>Results</i>: The results showed negative correlations between hepatic fat content and SMI% (r = −0.42, <i>p</i> < 0.001), ASM% (r = −0.29, <i>p</i> = 0.005), maximal voluntary force of grip (r = −0.22, <i>p</i> = 0.037), and knee extensors (r = −0.22, <i>p</i> = 0.032). <i>Conclusions</i>: These significant correlations almost remained unchanged even after controlling for insulin resistance. In conclusion, negative correlations exist between muscle mass/strength and the progressed severity of non-alcoholic fatty liver disease among post-menopausal women, and the correlations are independent of insulin resistance. |
topic |
grip strength knee extensors sarcopenia middle-aged women |
url |
https://www.mdpi.com/1010-660X/55/10/629 |
work_keys_str_mv |
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