Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020
Relatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10–September 11, 2020, we recruited 2,214 participants for a representative household-based cross-sectional serosurvey in Juba, South Suda...
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doaj-67620532719c41ceab539a4d2aafd64c2021-05-20T01:04:29ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592021-06-012761598160610.3201/eid2706.210568Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020Kirsten E. WiensPinyi Nyimol MawienJohn RumunuDamien SlaterForrest K. JonesSerina MoheedAndrea CaflischBior K. BiorIboyi Amanya JacobRichard Lino LakoArgata Guracha GuyoOlushayo Oluseun OluSylvester MaleghemiAndrew BagumaJuma John HassenSheila K. BayaLul DengJustin LesslerMaya N. DembyVanessa SanchezRachel MillsClare FraserRichelle C. CharlesJason B. HarrisAndrew S. AzmanJoseph F. Wamala Relatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10–September 11, 2020, we recruited 2,214 participants for a representative household-based cross-sectional serosurvey in Juba, South Sudan. We found 22.3% of participants had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain IgG titers above prepandemic levels. After accounting for waning antibody levels, age, and sex, we estimated that 38.3% (95% credible interval 31.8%–46.5%) of the population had been infected with SARS-CoV-2. At this rate, for each PCR–confirmed SARS-CoV-2 infection reported by the Ministry of Health, 103 (95% credible interval 86–126) infections would have been unreported, meaning SARS-CoV-2 has likely spread extensively within Juba. We also found differences in background reactivity in Juba compared with Boston, Massachusetts, USA, where the immunoassay was validated. Our findings underscore the need to validate serologic tests in sub-Saharan Africa populations. https://wwwnc.cdc.gov/eid/article/27/6/21-0568_articleantibodiescoronavirus diseaseCOVID-19influenzaJubarespiratory infections |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kirsten E. Wiens Pinyi Nyimol Mawien John Rumunu Damien Slater Forrest K. Jones Serina Moheed Andrea Caflisch Bior K. Bior Iboyi Amanya Jacob Richard Lino Lako Argata Guracha Guyo Olushayo Oluseun Olu Sylvester Maleghemi Andrew Baguma Juma John Hassen Sheila K. Baya Lul Deng Justin Lessler Maya N. Demby Vanessa Sanchez Rachel Mills Clare Fraser Richelle C. Charles Jason B. Harris Andrew S. Azman Joseph F. Wamala |
spellingShingle |
Kirsten E. Wiens Pinyi Nyimol Mawien John Rumunu Damien Slater Forrest K. Jones Serina Moheed Andrea Caflisch Bior K. Bior Iboyi Amanya Jacob Richard Lino Lako Argata Guracha Guyo Olushayo Oluseun Olu Sylvester Maleghemi Andrew Baguma Juma John Hassen Sheila K. Baya Lul Deng Justin Lessler Maya N. Demby Vanessa Sanchez Rachel Mills Clare Fraser Richelle C. Charles Jason B. Harris Andrew S. Azman Joseph F. Wamala Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 Emerging Infectious Diseases antibodies coronavirus disease COVID-19 influenza Juba respiratory infections |
author_facet |
Kirsten E. Wiens Pinyi Nyimol Mawien John Rumunu Damien Slater Forrest K. Jones Serina Moheed Andrea Caflisch Bior K. Bior Iboyi Amanya Jacob Richard Lino Lako Argata Guracha Guyo Olushayo Oluseun Olu Sylvester Maleghemi Andrew Baguma Juma John Hassen Sheila K. Baya Lul Deng Justin Lessler Maya N. Demby Vanessa Sanchez Rachel Mills Clare Fraser Richelle C. Charles Jason B. Harris Andrew S. Azman Joseph F. Wamala |
author_sort |
Kirsten E. Wiens |
title |
Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 |
title_short |
Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 |
title_full |
Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 |
title_fullStr |
Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 |
title_full_unstemmed |
Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 2020 |
title_sort |
seroprevalence of severe acute respiratory syndrome coronavirus 2 igg in juba, south sudan, 2020 |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2021-06-01 |
description |
Relatively few coronavirus disease cases and deaths have been reported from sub-Saharan Africa, although the extent of its spread remains unclear. During August 10–September 11, 2020, we recruited 2,214 participants for a representative household-based cross-sectional serosurvey in Juba, South Sudan. We found 22.3% of participants had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain IgG titers above prepandemic levels. After accounting for waning antibody levels, age, and sex, we estimated that 38.3% (95% credible interval 31.8%–46.5%) of the population had been infected with SARS-CoV-2. At this rate, for each PCR–confirmed SARS-CoV-2 infection reported by the Ministry of Health, 103 (95% credible interval 86–126) infections would have been unreported, meaning SARS-CoV-2 has likely spread extensively within Juba. We also found differences in background reactivity in Juba compared with Boston, Massachusetts, USA, where the immunoassay was validated. Our findings underscore the need to validate serologic tests in sub-Saharan Africa populations.
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topic |
antibodies coronavirus disease COVID-19 influenza Juba respiratory infections |
url |
https://wwwnc.cdc.gov/eid/article/27/6/21-0568_article |
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