Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice
Population aging results in urgent needs of interventions aimed at ensuring healthy senescence. Exercise often results in healthy aging, yet many molecular mechanisms underlying such effects still need to be identified. We here investigated whether the age-dependent accumulation of oxidative and met...
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Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2016/3837623 |
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doaj-676a8d262ce044e9ba97489bcb4adb612020-11-25T00:14:37ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/38376233837623Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging MiceS. Falone0S. Jr Santini1V. Cordone2M. Grannonico3M. Cacchio4G. Di Emidio5C. Tatone6F. Amicarelli7Department of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USADepartment of Biomedical Sciences, “G. d’Annunzio” University, Via dei Vestini, Chieti Scalo, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, L’Aquila, ItalyPopulation aging results in urgent needs of interventions aimed at ensuring healthy senescence. Exercise often results in healthy aging, yet many molecular mechanisms underlying such effects still need to be identified. We here investigated whether the age-dependent accumulation of oxidative and methylglyoxal- (MG-) related molecular damage could be delayed by moderate exercise in the mouse ovary, an organ that first exhibits impaired function with advancing age in mammals. CD1 female mice underwent two- or four-month treadmill-based running through the transition from adult to middle age, when ovaries show signs of senescence, and markers of protection against reactive oxygen species (ROS) and MG were measured. The long-term exercise reduced the protein oxidative damage in the ovaries (P<0.01), and this was linked to the preservation of the glutathione peroxidase protection against ROS (P<0.001), as well as to the increased glutathione availability (P<0.001). Conversely, even though the age-related deactivation of the MG-targeting systems was partially prevented by the long-term running programme (P<0.001), exercised mice were not protected from the age-dependent glycative burden. In summary, lately initiated regular and moderate exercise limited some changes occurring in the ovaries of middle-aged mice, and this might help to develop nonpharmacological cointerventions to reduce the vulnerability of mammalian ovaries towards redox dysfunctions.http://dx.doi.org/10.1155/2016/3837623 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
S. Falone S. Jr Santini V. Cordone M. Grannonico M. Cacchio G. Di Emidio C. Tatone F. Amicarelli |
spellingShingle |
S. Falone S. Jr Santini V. Cordone M. Grannonico M. Cacchio G. Di Emidio C. Tatone F. Amicarelli Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice Oxidative Medicine and Cellular Longevity |
author_facet |
S. Falone S. Jr Santini V. Cordone M. Grannonico M. Cacchio G. Di Emidio C. Tatone F. Amicarelli |
author_sort |
S. Falone |
title |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice |
title_short |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice |
title_full |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice |
title_fullStr |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice |
title_full_unstemmed |
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice |
title_sort |
regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2016-01-01 |
description |
Population aging results in urgent needs of interventions aimed at ensuring healthy senescence. Exercise often results in healthy aging, yet many molecular mechanisms underlying such effects still need to be identified. We here investigated whether the age-dependent accumulation of oxidative and methylglyoxal- (MG-) related molecular damage could be delayed by moderate exercise in the mouse ovary, an organ that first exhibits impaired function with advancing age in mammals. CD1 female mice underwent two- or four-month treadmill-based running through the transition from adult to middle age, when ovaries show signs of senescence, and markers of protection against reactive oxygen species (ROS) and MG were measured. The long-term exercise reduced the protein oxidative damage in the ovaries (P<0.01), and this was linked to the preservation of the glutathione peroxidase protection against ROS (P<0.001), as well as to the increased glutathione availability (P<0.001). Conversely, even though the age-related deactivation of the MG-targeting systems was partially prevented by the long-term running programme (P<0.001), exercised mice were not protected from the age-dependent glycative burden. In summary, lately initiated regular and moderate exercise limited some changes occurring in the ovaries of middle-aged mice, and this might help to develop nonpharmacological cointerventions to reduce the vulnerability of mammalian ovaries towards redox dysfunctions. |
url |
http://dx.doi.org/10.1155/2016/3837623 |
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