The Virtual Brain: a simulator of primate brain network dynamics
We present TheVirtualBrain (TVB), a neuroinformatics platform for full brainnetwork simulations using biologically realistic connectivity. This simulationenvironment enables the model-based inference of neurophysiological mechanismsacross different brain scales that underlie the generation of macros...
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doaj-676bf17c322343a298da3d40e5a25aa72020-11-25T00:29:15ZengFrontiers Media S.A.Frontiers in Neuroinformatics1662-51962013-06-01710.3389/fninf.2013.0001047900The Virtual Brain: a simulator of primate brain network dynamicsPaula eSanz Leon0Stuart A. Knock1M. Marmaduke Woodman2Lia eDomide3Jochen eMersmann4Anthony R. McIntosh5Viktor eJirsa6Aix Marseille UniversitéCharité University Medicine BerlinAix Marseille UniversitéCodemartCodebox GmbHRotman Research Institute at BaycrestAix Marseille UniversitéWe present TheVirtualBrain (TVB), a neuroinformatics platform for full brainnetwork simulations using biologically realistic connectivity. This simulationenvironment enables the model-based inference of neurophysiological mechanismsacross different brain scales that underlie the generation of macroscopicneuroimaging signals including functional MRI (fMRI), EEG and MEG. Researchersfrom different backgrounds can benefit from an integrative software platformincluding a supporting framework for data management (generation,organization, storage, integration and sharing) and a simulation core writtenin Python. TVB allows the reproduction and evaluation of personalizedconfigurations of the brain by using individual subject data. Thispersonalization facilitates an exploration of the consequences of pathologicalchanges in the system, permitting to investigate potential ways to counteractsuch unfavorable processes. The architecture of TVB supports interaction withMATLAB packages, for example, the well known Brain Connectivity Toolbox. TVBcan be used in a client-server configuration, such that it can be remotelyaccessed through the Internet thanks to its web-basedHTML5, JS and WebGL graphical user interface. TVB is alsoaccessible as a standalone cross-platform Python library and application, andusers can interact with the scientific core through the scripting interfaceIDLE, enabling easy modeling, development and debugging of the scientifickernel. This second interface makes TVB extensible by combining it with otherlibraries and modules developed by the Python scientific community. In this article, we describe the theoretical background and foundations that led to thedevelopment of TVB, the architecture and features of its major softwarecomponents as well as potential neuroscience applications.http://journal.frontiersin.org/Journal/10.3389/fninf.2013.00010/fullconnectivityconnectomepythonneural fieldvirtual brainneural mass |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paula eSanz Leon Stuart A. Knock M. Marmaduke Woodman Lia eDomide Jochen eMersmann Anthony R. McIntosh Viktor eJirsa |
spellingShingle |
Paula eSanz Leon Stuart A. Knock M. Marmaduke Woodman Lia eDomide Jochen eMersmann Anthony R. McIntosh Viktor eJirsa The Virtual Brain: a simulator of primate brain network dynamics Frontiers in Neuroinformatics connectivity connectome python neural field virtual brain neural mass |
author_facet |
Paula eSanz Leon Stuart A. Knock M. Marmaduke Woodman Lia eDomide Jochen eMersmann Anthony R. McIntosh Viktor eJirsa |
author_sort |
Paula eSanz Leon |
title |
The Virtual Brain: a simulator of primate brain network dynamics |
title_short |
The Virtual Brain: a simulator of primate brain network dynamics |
title_full |
The Virtual Brain: a simulator of primate brain network dynamics |
title_fullStr |
The Virtual Brain: a simulator of primate brain network dynamics |
title_full_unstemmed |
The Virtual Brain: a simulator of primate brain network dynamics |
title_sort |
virtual brain: a simulator of primate brain network dynamics |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroinformatics |
issn |
1662-5196 |
publishDate |
2013-06-01 |
description |
We present TheVirtualBrain (TVB), a neuroinformatics platform for full brainnetwork simulations using biologically realistic connectivity. This simulationenvironment enables the model-based inference of neurophysiological mechanismsacross different brain scales that underlie the generation of macroscopicneuroimaging signals including functional MRI (fMRI), EEG and MEG. Researchersfrom different backgrounds can benefit from an integrative software platformincluding a supporting framework for data management (generation,organization, storage, integration and sharing) and a simulation core writtenin Python. TVB allows the reproduction and evaluation of personalizedconfigurations of the brain by using individual subject data. Thispersonalization facilitates an exploration of the consequences of pathologicalchanges in the system, permitting to investigate potential ways to counteractsuch unfavorable processes. The architecture of TVB supports interaction withMATLAB packages, for example, the well known Brain Connectivity Toolbox. TVBcan be used in a client-server configuration, such that it can be remotelyaccessed through the Internet thanks to its web-basedHTML5, JS and WebGL graphical user interface. TVB is alsoaccessible as a standalone cross-platform Python library and application, andusers can interact with the scientific core through the scripting interfaceIDLE, enabling easy modeling, development and debugging of the scientifickernel. This second interface makes TVB extensible by combining it with otherlibraries and modules developed by the Python scientific community. In this article, we describe the theoretical background and foundations that led to thedevelopment of TVB, the architecture and features of its major softwarecomponents as well as potential neuroscience applications. |
topic |
connectivity connectome python neural field virtual brain neural mass |
url |
http://journal.frontiersin.org/Journal/10.3389/fninf.2013.00010/full |
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