Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria
Incretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain. Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimen...
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Series: | International Journal of Endocrinology |
Online Access: | http://dx.doi.org/10.1155/2013/895102 |
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doaj-677169dd70a94d78928ddd69dc97ce7f2020-11-24T23:31:27ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/895102895102Renal Effects of DPP-4 Inhibitors: A Focus on MicroalbuminuriaMartin Haluzík0Jan Frolík1Ivan Rychlík2Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, U nemocnice 1, 120 00 Prague, Czech RepublicEli Lilly and Company, Pobrezni 12, 180 00 Prague, Czech RepublicThird Faculty of Medicine, Charles University, Srobarova 50, 100 34 Prague, Czech RepublicIncretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain. Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimental and small clinical studies including its beta-cell- and vasculo-protective actions. One of the recently emerged interesting features of dipeptidyl peptidase-4 (DPP-4) inhibitors is its possible protective effect on the diabetic kidney disease. Here, we review the renal effects of DPP-4 inhibitors with special focus on its influence on the onset and progression of microalbuminuria, as presence of microalbuminuria represents an important early sign of kidney damage and is also associated with increased risk of hypoglycemia and cardiovascular complications. Mechanisms underlying possible nephroprotective properties of DPP-4 inhibitors include reduction of oxidative stress and inflammation and improvement of endothelial dysfunction. Effects of DPP-4 inhibitors may be both glucagon-like peptide-1 (GLP-1) dependent and independent. Ongoing prospective studies focused on the nephroprotective effects of DPP-4 inhibitors will further clarify its possible role in the prevention/attenuation of diabetic kidney disease beyond its glucose lowering properties.http://dx.doi.org/10.1155/2013/895102 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Martin Haluzík Jan Frolík Ivan Rychlík |
spellingShingle |
Martin Haluzík Jan Frolík Ivan Rychlík Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria International Journal of Endocrinology |
author_facet |
Martin Haluzík Jan Frolík Ivan Rychlík |
author_sort |
Martin Haluzík |
title |
Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria |
title_short |
Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria |
title_full |
Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria |
title_fullStr |
Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria |
title_full_unstemmed |
Renal Effects of DPP-4 Inhibitors: A Focus on Microalbuminuria |
title_sort |
renal effects of dpp-4 inhibitors: a focus on microalbuminuria |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2013-01-01 |
description |
Incretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain. Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimental and small clinical studies including its beta-cell- and vasculo-protective actions. One of the recently emerged interesting features of dipeptidyl peptidase-4 (DPP-4) inhibitors is its possible protective effect on the diabetic kidney disease. Here, we review the renal effects of DPP-4 inhibitors with special focus on its influence on the onset and progression of microalbuminuria, as presence of microalbuminuria represents an important early sign of kidney damage and is also associated with increased risk of hypoglycemia and cardiovascular complications. Mechanisms underlying possible nephroprotective properties of DPP-4 inhibitors include reduction of oxidative stress and inflammation and improvement of endothelial dysfunction. Effects of DPP-4 inhibitors may be both glucagon-like peptide-1 (GLP-1) dependent and independent. Ongoing prospective studies focused on the nephroprotective effects of DPP-4 inhibitors will further clarify its possible role in the prevention/attenuation of diabetic kidney disease beyond its glucose lowering properties. |
url |
http://dx.doi.org/10.1155/2013/895102 |
work_keys_str_mv |
AT martinhaluzik renaleffectsofdpp4inhibitorsafocusonmicroalbuminuria AT janfrolik renaleffectsofdpp4inhibitorsafocusonmicroalbuminuria AT ivanrychlik renaleffectsofdpp4inhibitorsafocusonmicroalbuminuria |
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1725538018053324800 |