Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study
Abstract Background In patients with Normal Glucose Tolerance (NGT) some causes of ischemic heart disease (IHD) were not completely investigated. The role both of metabolic milieu and adipokines in IHD progression was not fully investigated. Our aim was to assess the link between adipokines plasma l...
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Format: | Article |
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BMC
2019-03-01
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Series: | Cardiovascular Diabetology |
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Online Access: | http://link.springer.com/article/10.1186/s12933-019-0826-0 |
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doaj-677bcdb3799340f99bae19e9127001f6 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ferdinando Carlo Sasso Pia Clara Pafundi Raffaele Marfella Paolo Calabrò Federico Piscione Fulvio Furbatto Giovanni Esposito Raffaele Galiero Felice Gragnano Luca Rinaldi Teresa Salvatore Michele D’Amico Luigi Elio Adinolfi Celestino Sardu |
spellingShingle |
Ferdinando Carlo Sasso Pia Clara Pafundi Raffaele Marfella Paolo Calabrò Federico Piscione Fulvio Furbatto Giovanni Esposito Raffaele Galiero Felice Gragnano Luca Rinaldi Teresa Salvatore Michele D’Amico Luigi Elio Adinolfi Celestino Sardu Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study Cardiovascular Diabetology Percutaneous coronary intervention Insulin resistance Adipokines Restenosis Glucose tolerance |
author_facet |
Ferdinando Carlo Sasso Pia Clara Pafundi Raffaele Marfella Paolo Calabrò Federico Piscione Fulvio Furbatto Giovanni Esposito Raffaele Galiero Felice Gragnano Luca Rinaldi Teresa Salvatore Michele D’Amico Luigi Elio Adinolfi Celestino Sardu |
author_sort |
Ferdinando Carlo Sasso |
title |
Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study |
title_short |
Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study |
title_full |
Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study |
title_fullStr |
Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study |
title_full_unstemmed |
Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE Study |
title_sort |
adiponectin and insulin resistance are related to restenosis and overall new pci in subjects with normal glucose tolerance: the prospective aire study |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2019-03-01 |
description |
Abstract Background In patients with Normal Glucose Tolerance (NGT) some causes of ischemic heart disease (IHD) were not completely investigated. The role both of metabolic milieu and adipokines in IHD progression was not fully investigated. Our aim was to assess the link between adipokines plasma levels, insulin resistance (IR) and IHD in NGT patients undergoing Percutaneous Coronary Intervention (PCI). Methods AIRE is a single-center prospective longitudinal observational study investigating the IHD outcome of NGT subjects who underwent coronary revascularization by PCI in a third level cardiology center at A.O. dei Colli Hospital, University of Campania “Luigi Vanvitelli”. Six hundred seventy-nine subjects hospitalized in 2015 for coronary arteriography not suffering from Acute Coronary Syndrome (ACS) in the previous 4 weeks, as well as from all conditions could affect glycemic plasma levels and IR status, were assessed for eligibility. Fifty-four patients with neither history of diabetes nor Altered Fasting Glucose (AFG)/Impaired Fasting Glucose (IGT) after Oral Glucose Tolerance Test (OGTT) were finally enrolled. Primary endpoint was the assessment of the relationship of adipokines and HOMA-IR with the occurrence of restenosis in NGT subjects. As secondary endpoint we assessed the association of the same adipokines and IR with overall ACS events after PCI in NGT subjects. Results The 54 NGT patients enrolled were mainly males (85%), with a median age of 60 years [IQR 58–63 years]. Only 4 patients (7.4%) experimented restenosis. Median follow-up was equal to 29.5 months [IQR 14.7–34 months]. Adiponectin levels were independently associated to restenosis (OR 0.206; 95% CI 0.053–0.796; p = 0.000). Instead HOMA-IR and adiponectin appeared independently associated both to de novo IHD (OR 9.6*1013; 95% CI 3.026–3.08*1027; p = 0.042 and OR 0.206; 95% CI 0.053–0.796; p = 0.000, respectively) and overall new PCI (OR 1.5*1011; 95% CI 2.593–8.68*1021; p = 0.042 and OR 0.206; 95% CI 0.053–0.796; p = 0.000, respectively). Moreover, we fixed a potential cut-off for adiponectin for risk of restenosis (≤ 8.5 µg/mL) and overall new PCI (≤ 9.5 µg/mL). Conclusion IR and cytokines play a role in progression of any stage of IHD also in NGT subjects. Our results in this setting of patients, though the relatively small sample size, represent a novelty. Future studies on larger populations are needed to analyze more in depth adipokines and insulin resistance role on IHD progression in non-diabetic people. |
topic |
Percutaneous coronary intervention Insulin resistance Adipokines Restenosis Glucose tolerance |
url |
http://link.springer.com/article/10.1186/s12933-019-0826-0 |
work_keys_str_mv |
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doaj-677bcdb3799340f99bae19e9127001f62020-11-25T01:57:44ZengBMCCardiovascular Diabetology1475-28402019-03-0118111310.1186/s12933-019-0826-0Adiponectin and insulin resistance are related to restenosis and overall new PCI in subjects with normal glucose tolerance: the prospective AIRE StudyFerdinando Carlo Sasso0Pia Clara Pafundi1Raffaele Marfella2Paolo Calabrò3Federico Piscione4Fulvio Furbatto5Giovanni Esposito6Raffaele Galiero7Felice Gragnano8Luca Rinaldi9Teresa Salvatore10Michele D’Amico11Luigi Elio Adinolfi12Celestino Sardu13Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”University of Campania “Luigi Vanvitelli”Division of Cardiology, A.O.R.N. Sant’Anna e San SebastianoDepartment of Medicine and Surgery, University of SalernoDepartment of Cardiology, Cardarelli HospitalDepartment of Advanced Biomedical Sciences, University of Naples “Federico II”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Division of Cardiology, A.O.R.N. Sant’Anna e San SebastianoDepartment of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Abstract Background In patients with Normal Glucose Tolerance (NGT) some causes of ischemic heart disease (IHD) were not completely investigated. The role both of metabolic milieu and adipokines in IHD progression was not fully investigated. Our aim was to assess the link between adipokines plasma levels, insulin resistance (IR) and IHD in NGT patients undergoing Percutaneous Coronary Intervention (PCI). Methods AIRE is a single-center prospective longitudinal observational study investigating the IHD outcome of NGT subjects who underwent coronary revascularization by PCI in a third level cardiology center at A.O. dei Colli Hospital, University of Campania “Luigi Vanvitelli”. Six hundred seventy-nine subjects hospitalized in 2015 for coronary arteriography not suffering from Acute Coronary Syndrome (ACS) in the previous 4 weeks, as well as from all conditions could affect glycemic plasma levels and IR status, were assessed for eligibility. Fifty-four patients with neither history of diabetes nor Altered Fasting Glucose (AFG)/Impaired Fasting Glucose (IGT) after Oral Glucose Tolerance Test (OGTT) were finally enrolled. Primary endpoint was the assessment of the relationship of adipokines and HOMA-IR with the occurrence of restenosis in NGT subjects. As secondary endpoint we assessed the association of the same adipokines and IR with overall ACS events after PCI in NGT subjects. Results The 54 NGT patients enrolled were mainly males (85%), with a median age of 60 years [IQR 58–63 years]. Only 4 patients (7.4%) experimented restenosis. Median follow-up was equal to 29.5 months [IQR 14.7–34 months]. Adiponectin levels were independently associated to restenosis (OR 0.206; 95% CI 0.053–0.796; p = 0.000). Instead HOMA-IR and adiponectin appeared independently associated both to de novo IHD (OR 9.6*1013; 95% CI 3.026–3.08*1027; p = 0.042 and OR 0.206; 95% CI 0.053–0.796; p = 0.000, respectively) and overall new PCI (OR 1.5*1011; 95% CI 2.593–8.68*1021; p = 0.042 and OR 0.206; 95% CI 0.053–0.796; p = 0.000, respectively). Moreover, we fixed a potential cut-off for adiponectin for risk of restenosis (≤ 8.5 µg/mL) and overall new PCI (≤ 9.5 µg/mL). Conclusion IR and cytokines play a role in progression of any stage of IHD also in NGT subjects. Our results in this setting of patients, though the relatively small sample size, represent a novelty. Future studies on larger populations are needed to analyze more in depth adipokines and insulin resistance role on IHD progression in non-diabetic people.http://link.springer.com/article/10.1186/s12933-019-0826-0Percutaneous coronary interventionInsulin resistanceAdipokinesRestenosisGlucose tolerance |