How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer?
Over the last three decades, a series of clinical trials have led to the use of adjuvant pelvic radiotherapy and chemotherapy in high-risk (T3-4 or N1) rectal cancer. There is a need to improve patient selection in order to identify the group most at risk for recurrent disease. The toxicity of adjuv...
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doaj-67842ebc87f944e7b0f7e052c9cee75a2020-11-25T00:07:55ZengElsevierAsian Journal of Surgery1015-95842004-04-0127214716110.1016/S1015-9584(09)60331-6How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer?Michael W.T. Chao0Joe J. Tjandra1Peter Gibbs2Stephen McLaughlin3Radiation Oncology Victoria, East Melbourne, AustraliaDepartment of Colorectal Surgery, Royal Melbourne Hospital, Melbourne, AustraliaDepartment of Medical Oncology, Royal Melbourne Hospital, Melbourne, AustraliaDepartment of Colorectal Surgery, Western Hospital, Melbourne, AustraliaOver the last three decades, a series of clinical trials have led to the use of adjuvant pelvic radiotherapy and chemotherapy in high-risk (T3-4 or N1) rectal cancer. There is a need to improve patient selection in order to identify the group most at risk for recurrent disease. The toxicity of adjuvant therapy should be factored into this consideration. The optimal sequencing of adjuvant therapy before or after surgery, the use of short- or long-course radiotherapy, and the utility of concurrent chemotherapy is currently being examined in randomized controlled trials (RCTs). The aim of this report was to review the morbidity and mortality in all RCTs of adjuvant therapy for rectal cancer.http://www.sciencedirect.com/science/article/pii/S1015958409603316 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael W.T. Chao Joe J. Tjandra Peter Gibbs Stephen McLaughlin |
spellingShingle |
Michael W.T. Chao Joe J. Tjandra Peter Gibbs Stephen McLaughlin How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? Asian Journal of Surgery |
author_facet |
Michael W.T. Chao Joe J. Tjandra Peter Gibbs Stephen McLaughlin |
author_sort |
Michael W.T. Chao |
title |
How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? |
title_short |
How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? |
title_full |
How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? |
title_fullStr |
How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? |
title_full_unstemmed |
How Safe is Adjuvant Chemotherapy and Radiotherapy for Rectal Cancer? |
title_sort |
how safe is adjuvant chemotherapy and radiotherapy for rectal cancer? |
publisher |
Elsevier |
series |
Asian Journal of Surgery |
issn |
1015-9584 |
publishDate |
2004-04-01 |
description |
Over the last three decades, a series of clinical trials have led to the use of adjuvant pelvic radiotherapy and chemotherapy in high-risk (T3-4 or N1) rectal cancer. There is a need to improve patient selection in order to identify the group most at risk for recurrent disease. The toxicity of adjuvant therapy should be factored into this consideration. The optimal sequencing of adjuvant therapy before or after surgery, the use of short- or long-course radiotherapy, and the utility of concurrent chemotherapy is currently being examined in randomized controlled trials (RCTs). The aim of this report was to review the morbidity and mortality in all RCTs of adjuvant therapy for rectal cancer. |
url |
http://www.sciencedirect.com/science/article/pii/S1015958409603316 |
work_keys_str_mv |
AT michaelwtchao howsafeisadjuvantchemotherapyandradiotherapyforrectalcancer AT joejtjandra howsafeisadjuvantchemotherapyandradiotherapyforrectalcancer AT petergibbs howsafeisadjuvantchemotherapyandradiotherapyforrectalcancer AT stephenmclaughlin howsafeisadjuvantchemotherapyandradiotherapyforrectalcancer |
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