Cromatografia em leito móvel simulado na produção de substâncias enantiomericamente puras ou enriquecidas em larga escala

• Main Authors: Ivanildo José da Silva Junior, Vinícius de Veredas, Marco Antônio Garcia dos Santos, Cesar Costapinto Santana, Marcos José Souza Carpes, Carlos Roque Duarte Correia
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2006-10-01
• Series: Química Nova
• Subjects: enantiomer separations; chiral stationary phases; liquid chromatography
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500024&lng=en&tlng=en

There is great interest nowadays in the use of preparative liquid chromatography as an effective tool for the production of enantiomerically pure, or enriched, compounds for the pharmaceutical industry. To make the chromatographic process economically attractive, attention is now focused on the choice of the chromatographic operating mode to minimize eluent consumption and to maximize productivity. Among the alternatives to the traditional batch chromatography, attention is now shifting towards simulated moving bed (SMB) technologies and a review covering the latest developments in this area seems timely. Several aspects of this important analytical technique are presented and details concerning the SMB technology for process optimization are outlined.