A magnetic bead-integrated chip for the large scale manufacture of normalized esiRNAs.
The chemically-synthesized siRNA duplex has become a powerful and widely used tool for RNAi loss-of-function studies, but suffers from a high off-target effect problem. Recently, endoribonulease-prepared siRNA (esiRNA) has been shown to be an attractive alternative due to its lower off-target effect...
Main Authors: | Zhao Wang, Huang Huang, Hanshuo Zhang, Changhong Sun, Yang Hao, Junyu Yang, Yu Fan, Jianzhong Jeff Xi |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3384639?pdf=render |
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