In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study

In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study

Abstract Background Magnetic resonance imaging (MRI)-guided pulsed focused ultrasound combined with the infusion of microbubbles (pFUS+MB) induces transient blood-brain barrier opening (BBBO) in targeted regions. pFUS+MB, through the facilitation of neurotherapeutics’ delivery, has been advocated as...

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Bibliographic Details
Main Authors: Sanhita Sinharay, Tsang-Wei Tu, Zsofia I. Kovacs, William Schreiber-Stainthorp, Maggie Sundby, Xiang Zhang, Georgios Z. Papadakis, William C. Reid, Joseph A. Frank, Dima A. Hammoud
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
[18F]DPA-714 PET
Pulsed focused ultrasound
Magnetic resonance imaging
Translocator protein
Online Access:http://link.springer.com/article/10.1186/s12974-019-1543-z

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