Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract

The present study investigates the effect of ludartin on spinal cord injury in rat model. Ludartin treatment decreased the expression of myeloperoxidase and malondialdehyde in spinal cord tissues. The expression of glutathione and superoxide dismutase was enhanced. It also exhibited inhibitory effe...

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Main Authors:	Jae Sung Pyo, Hyung Hoi Kim, Kang Min Kim, Jae Seon Kang
Format:	Article
Language:	English
Published:	Bangladesh Pharmacological Society 2019-04-01
Series:	Bangladesh Journal of Pharmacology
Subjects:	Cultivated wild ginseng Ginsenosides Compound K Dry eye syndrome
Online Access:	https://www.banglajol.info/index.php/BJP/article/view/39034

id	doaj-67a2731f6d8a4db2b0f6a0c671e825ee
record_format	Article
spelling	doaj-67a2731f6d8a4db2b0f6a0c671e825ee2020-11-24T21:42:22ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882019-04-0114210.3329/bjp.v14i2.39034Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extractJae Sung Pyo0Hyung Hoi Kim1Kang Min Kim2Jae Seon Kang3Department of Pharmacy, Kyungsung University, Busan 48434, South KoreaDepartment of Laboratory Medicine and Biomedical Research Institute, Pusan National University Hospital, 50612, South KoreaDepartment of Pharmaceutical Science and Technology, Kyungsung University, Busan, South KoreaDepartment of Pharmacy, Kyungsung University, Busan 48434, South Korea The present study investigates the effect of ludartin on spinal cord injury in rat model. Ludartin treatment decreased the expression of myeloperoxidase and malondialdehyde in spinal cord tissues. The expression of glutathione and superoxide dismutase was enhanced. It also exhibited inhibitory effect on reduction of NeuN-positive cells. The proportion of TUNEL positive cells was also regulated. In addition, ludartin treatment prevented the onset of apoptosis which was evident by decrease in caspase-3 and Bax level and increase of Bcl‑2 level. Up-regulation of tumor necrosis factor‑α, inter-leukin‑1β and I interleukin‑6 by spinal cord injury was suppressed by ludartin treatment. There was improvement in locomotion of rats by treatment with ludartin. Ludartin treatment of spinal cord injury rats improves locomotion by inhibiting inflammatory cytokine expression and preventing cell apoptosis. Thus, ludartin has therapeutic importance in spinal cord injury treatment. https://www.banglajol.info/index.php/BJP/article/view/39034Cultivated wild ginsengGinsenosidesCompound KDry eye syndrome
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jae Sung Pyo Hyung Hoi Kim Kang Min Kim Jae Seon Kang
spellingShingle	Jae Sung Pyo Hyung Hoi Kim Kang Min Kim Jae Seon Kang Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract Bangladesh Journal of Pharmacology Cultivated wild ginseng Ginsenosides Compound K Dry eye syndrome
author_facet	Jae Sung Pyo Hyung Hoi Kim Kang Min Kim Jae Seon Kang
author_sort	Jae Sung Pyo
title	Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
title_short	Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
title_full	Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
title_fullStr	Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
title_full_unstemmed	Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
title_sort	amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract
publisher	Bangladesh Pharmacological Society
series	Bangladesh Journal of Pharmacology
issn	1991-0088
publishDate	2019-04-01
description	The present study investigates the effect of ludartin on spinal cord injury in rat model. Ludartin treatment decreased the expression of myeloperoxidase and malondialdehyde in spinal cord tissues. The expression of glutathione and superoxide dismutase was enhanced. It also exhibited inhibitory effect on reduction of NeuN-positive cells. The proportion of TUNEL positive cells was also regulated. In addition, ludartin treatment prevented the onset of apoptosis which was evident by decrease in caspase-3 and Bax level and increase of Bcl‑2 level. Up-regulation of tumor necrosis factor‑α, inter-leukin‑1β and I interleukin‑6 by spinal cord injury was suppressed by ludartin treatment. There was improvement in locomotion of rats by treatment with ludartin. Ludartin treatment of spinal cord injury rats improves locomotion by inhibiting inflammatory cytokine expression and preventing cell apoptosis. Thus, ludartin has therapeutic importance in spinal cord injury treatment.
topic	Cultivated wild ginseng Ginsenosides Compound K Dry eye syndrome
url	https://www.banglajol.info/index.php/BJP/article/view/39034
work_keys_str_mv	AT jaesungpyo ameliorationofdryeyesyndromebyoraladministrationofcultivatedwildginsengextract AT hyunghoikim ameliorationofdryeyesyndromebyoraladministrationofcultivatedwildginsengextract AT kangminkim ameliorationofdryeyesyndromebyoraladministrationofcultivatedwildginsengextract AT jaeseonkang ameliorationofdryeyesyndromebyoraladministrationofcultivatedwildginsengextract
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Amelioration of dry eye syndrome by oral administration of cultivated wild ginseng extract

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