Comparison of Interleukin-1β Levels in Gingival Crevicular Fluid and Peri-Implant Crevicular Fluid and Its Relationship with Clinical Indexes

• Main Authors: Mojgan Paknejad, Afshin Khorsand, Siamak Yaghobee
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2013-01-01
• Series: Journal of Dentistry of Tehran University of Medical Sciences
• Subjects: Interleukin-1beta; Gingival Crevicular Fluid; Peri-Implantitis
• Online Access: http://jdt.tums.ac.ir/index.php/jdt/article/view/587/388

Objective: Interleukin-1 (IL-1 ) is one of the most important cytokines which seems to have an important role in the inflammatory process in gingival and peri-implant tissues. The aim of this split-mouth study was to investigate the relationship between the concentration of IL-1 in gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) and clinical parameters such as plaque index (PI), gingival index (GI), pocket depth (PD) and bone loss (BL).Materials and Methods: In 32 patients, PICF and GCF samples of 41 implants and 41 contralateral teeth were collected and IL-1 was determined by enzyme-linked immunosorbent assay (ELISA). PI, GI, PD and BL were recorded for each of the samples.Result :The positive correlation between the level of IL-1 and PI, GI, PD and BL in both groups was observed (P<0.0001). In similar conditions, the level of IL-1 was greatly higher in PICF than GCF (75.26 pg/ and 45.71 pg/ , respectively) (P=0.001).Conclusion: The findings of the present study indicated that the level of IL-1 may be an important supplement to clinical findings in measuring the health status of gingival or peri-implant tissues.