Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study
Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of...
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Frontiers Media S.A.
2021-06-01
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Series: | Frontiers in Cardiovascular Medicine |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.682521/full |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bianca Dahlen Felix Müller Felix Müller Sven-Oliver Tröbs Sven-Oliver Tröbs Sven-Oliver Tröbs Marc William Heidorn Marc William Heidorn Andreas Schulz Natalie Arnold Natalie Arnold M. Iris Hermanns Sören Schwuchow-Thonke Jürgen H. Prochaska Jürgen H. Prochaska Jürgen H. Prochaska Tommaso Gori Tommaso Gori Hugo ten Cate Karl J. Lackner Karl J. Lackner Thomas Münzel Thomas Münzel Philipp S. Wild Philipp S. Wild Philipp S. Wild Marina Panova-Noeva Marina Panova-Noeva |
spellingShingle |
Bianca Dahlen Felix Müller Felix Müller Sven-Oliver Tröbs Sven-Oliver Tröbs Sven-Oliver Tröbs Marc William Heidorn Marc William Heidorn Andreas Schulz Natalie Arnold Natalie Arnold M. Iris Hermanns Sören Schwuchow-Thonke Jürgen H. Prochaska Jürgen H. Prochaska Jürgen H. Prochaska Tommaso Gori Tommaso Gori Hugo ten Cate Karl J. Lackner Karl J. Lackner Thomas Münzel Thomas Münzel Philipp S. Wild Philipp S. Wild Philipp S. Wild Marina Panova-Noeva Marina Panova-Noeva Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study Frontiers in Cardiovascular Medicine heart failure MPV platelet count parathyroid hormone heart failure with preserved ejection fraction heart failure with reduced ejection fraction |
author_facet |
Bianca Dahlen Felix Müller Felix Müller Sven-Oliver Tröbs Sven-Oliver Tröbs Sven-Oliver Tröbs Marc William Heidorn Marc William Heidorn Andreas Schulz Natalie Arnold Natalie Arnold M. Iris Hermanns Sören Schwuchow-Thonke Jürgen H. Prochaska Jürgen H. Prochaska Jürgen H. Prochaska Tommaso Gori Tommaso Gori Hugo ten Cate Karl J. Lackner Karl J. Lackner Thomas Münzel Thomas Münzel Philipp S. Wild Philipp S. Wild Philipp S. Wild Marina Panova-Noeva Marina Panova-Noeva |
author_sort |
Bianca Dahlen |
title |
Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study |
title_short |
Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study |
title_full |
Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study |
title_fullStr |
Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study |
title_full_unstemmed |
Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study |
title_sort |
sex-specific relationship between parathyroid hormone and platelet indices in phenotypes of heart failure—results from the myovasc study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-06-01 |
description |
Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [β = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [β = −7.6 (−15; −0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets. |
topic |
heart failure MPV platelet count parathyroid hormone heart failure with preserved ejection fraction heart failure with reduced ejection fraction |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.682521/full |
work_keys_str_mv |
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doaj-67a7eef88b4a441081f76eaad80417192021-06-16T09:44:21ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-06-01810.3389/fcvm.2021.682521682521Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc StudyBianca Dahlen0Felix Müller1Felix Müller2Sven-Oliver Tröbs3Sven-Oliver Tröbs4Sven-Oliver Tröbs5Marc William Heidorn6Marc William Heidorn7Andreas Schulz8Natalie Arnold9Natalie Arnold10M. Iris Hermanns11Sören Schwuchow-Thonke12Jürgen H. Prochaska13Jürgen H. Prochaska14Jürgen H. Prochaska15Tommaso Gori16Tommaso Gori17Hugo ten Cate18Karl J. Lackner19Karl J. Lackner20Thomas Münzel21Thomas Münzel22Philipp S. Wild23Philipp S. Wild24Philipp S. Wild25Marina Panova-Noeva26Marina Panova-Noeva27Preventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyCardiology I, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyCardiology I, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyLaboratory for Clinical Thrombosis and Hemostasis, Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, NetherlandsDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyCardiology I, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyPreventive Cardiology and Preventive Medicine, Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyDZHK (German Center for Cardiovascular Research), Partner Site Rhine Main, Mainz, GermanyClinical Epidemiology and Systems Medicine, Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, GermanyBackground: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF.Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF.Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [β = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [β = −7.6 (−15; −0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF).Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.https://www.frontiersin.org/articles/10.3389/fcvm.2021.682521/fullheart failureMPVplatelet countparathyroid hormoneheart failure with preserved ejection fractionheart failure with reduced ejection fraction |