Lipid Transport through the Fetoplacental Barrier by the Fatty Acid-Binding Proteins in Pregnant Women with Herpes Virus Infection in the third Trimester

• Main Authors: Michael T. Lucenko, PhD, ScD, Irina A. Andrievskaya, PhD, ScD, Natalia A. Ishutina, PhD
• Format: Article
• Language: English
• Published: International Medical Research and Development Corporation 2012-12-01
• Series: International Journal of Biomedicine
• Subjects: fetoplacental unit; long chain polyunsaturated fatty acids; heart-type fatty acid-binding proteins; herpes virus infection.
• Online Access: http://www.ijbm.org/articles/2_4_BR2.pdf

In this study, the transport of the long chain polyunsaturated fatty acids (LCPUFAs) from the lacunar blood through the syncytiotrophoblast of the placental villi to the fetal cord blood via a saturable protein-mediated mechanism by the heart-type fatty acid-binding proteins (H-FABPs) has been examined. Exacerbation of the herpes simplex viruses (HSV-1) in the third trimester of gestation reduces the delivery of the fatty acid-binding proteins to the syncytiotrophoblast. During exacerbation of the HSV-1 infection, the selective transfer of the LCPUFAs across the syncytiotrophoblast basal plasma membrane into the fetal cord blood was observed. The supply of anti-inflammatory ω-3 PUFAs was reduced; however, the inflow of inflammatory arachidonic acid and other ω-6 PUFAs into the fetal blood was increased.