Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis
Abstract Many Parkinson’s disease (PD) patients are able to ride a bicycle despite being severely compromised by gait disturbances up to freezing of gait. This review [PROSPERO CRD 42019137386] aimed to find out, which PD-related symptoms improve from bicycling, and which type of bicycling exercise...
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2021-09-01
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Online Access: | https://doi.org/10.1038/s41531-021-00222-6 |
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doaj-67af8b8b78c6442cb0f87c7f560b59882021-09-26T11:34:13ZengNature Publishing Groupnpj Parkinson's Disease2373-80572021-09-017111010.1038/s41531-021-00222-6Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysisMarianne Tiihonen0Britta U. Westner1Markus Butz2Sarang S. Dalal3Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University DüsseldorfCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus UniversityInstitute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University DüsseldorfCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus UniversityAbstract Many Parkinson’s disease (PD) patients are able to ride a bicycle despite being severely compromised by gait disturbances up to freezing of gait. This review [PROSPERO CRD 42019137386] aimed to find out, which PD-related symptoms improve from bicycling, and which type of bicycling exercise would be most beneficial. Following a systematic database literature search, peer-reviewed studies with randomized control trials (RCT) and with non-randomized trials (NRCT) investigating the interventional effects of bicycling on PD patients were included. A quality analysis addressing reporting, design and possible bias of the studies, as well as a publication bias test was done. Out of 202 references, 22 eligible studies with 505 patients were analysed. An inverse variance-based analysis revealed that primary measures, defined as motor outcomes, benefitted from bicycling significantly more than cognitive measures. Additionally, secondary measures of balance, walking speed and capacity, and the PDQ-39 ratings improved with bicycling. The interventions varied in durations, intensities and target cadences. Conclusively, bicycling is particularly beneficial for the motor performance of PD patients, improving crucial features of gait. Furthermore, our findings suggest that bicycling improves the overall quality-of-life of PD patients.https://doi.org/10.1038/s41531-021-00222-6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marianne Tiihonen Britta U. Westner Markus Butz Sarang S. Dalal |
spellingShingle |
Marianne Tiihonen Britta U. Westner Markus Butz Sarang S. Dalal Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis npj Parkinson's Disease |
author_facet |
Marianne Tiihonen Britta U. Westner Markus Butz Sarang S. Dalal |
author_sort |
Marianne Tiihonen |
title |
Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
title_short |
Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
title_full |
Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
title_fullStr |
Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
title_full_unstemmed |
Parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
title_sort |
parkinson’s disease patients benefit from bicycling - a systematic review and meta-analysis |
publisher |
Nature Publishing Group |
series |
npj Parkinson's Disease |
issn |
2373-8057 |
publishDate |
2021-09-01 |
description |
Abstract Many Parkinson’s disease (PD) patients are able to ride a bicycle despite being severely compromised by gait disturbances up to freezing of gait. This review [PROSPERO CRD 42019137386] aimed to find out, which PD-related symptoms improve from bicycling, and which type of bicycling exercise would be most beneficial. Following a systematic database literature search, peer-reviewed studies with randomized control trials (RCT) and with non-randomized trials (NRCT) investigating the interventional effects of bicycling on PD patients were included. A quality analysis addressing reporting, design and possible bias of the studies, as well as a publication bias test was done. Out of 202 references, 22 eligible studies with 505 patients were analysed. An inverse variance-based analysis revealed that primary measures, defined as motor outcomes, benefitted from bicycling significantly more than cognitive measures. Additionally, secondary measures of balance, walking speed and capacity, and the PDQ-39 ratings improved with bicycling. The interventions varied in durations, intensities and target cadences. Conclusively, bicycling is particularly beneficial for the motor performance of PD patients, improving crucial features of gait. Furthermore, our findings suggest that bicycling improves the overall quality-of-life of PD patients. |
url |
https://doi.org/10.1038/s41531-021-00222-6 |
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