Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls

Immunosuppressive Functions of M2 Macrophages Derived from iPSCs of Patients with ALS and Healthy Controls

Summary: Amyotrophic lateral sclerosis (ALS) is a disorder with immune alterations that augment disease severity. M2 macrophages benefit diabetic and nephrotic mice by suppressing the pro-inflammatory state. However, neither have M2 cells been investigated in ALS nor have human induced pluripotent s...

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Bibliographic Details
Main Authors: Weihua Zhao, David R. Beers, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Jinghong Wang, Shixiang Wen, Loren Ornelas, Dhruv Sareen, Helen S. Goodridge, Clive N. Svendsen, Stanley H. Appel
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:iScience
Subjects:
Cellular Neuroscience
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220303771

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