Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response

Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response

Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for...

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Main Authors: Savarin Monika, Kamensek Urska, Cemazar Maja, Heller Richard, Sersa Gregor
Format: Article
Language:English
Published: Sciendo 2017-02-01
Series:Radiology and Oncology
Subjects:
gene therapy
electrotransfer
plasmid
irradiation
immune response
melanoma
Online Access:https://doi.org/10.1515/raon-2017-0011
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spelling doaj-67bd09d246944724bf4fdee653acffc32021-09-05T14:00:10ZengSciendoRadiology and Oncology1581-32072017-02-01511303910.1515/raon-2017-0011raon-2017-0011Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune responseSavarin Monika0Kamensek Urska1Cemazar Maja2Heller Richard3Sersa Gregor4Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaDepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, USADepartment of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, SloveniaTumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for silencing endoglin, with vascular targeted effectiveness, can radiosensitize melanoma B16F10 tumors.https://doi.org/10.1515/raon-2017-0011gene therapyelectrotransferplasmidirradiationimmune responsemelanoma
collection DOAJ
language English
format Article
sources DOAJ
author Savarin Monika
Kamensek Urska
Cemazar Maja
Heller Richard
Sersa Gregor
spellingShingle Savarin Monika
Kamensek Urska
Cemazar Maja
Heller Richard
Sersa Gregor
Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
Radiology and Oncology
gene therapy
electrotransfer
plasmid
irradiation
immune response
melanoma
author_facet Savarin Monika
Kamensek Urska
Cemazar Maja
Heller Richard
Sersa Gregor
author_sort Savarin Monika
title Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
title_short Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
title_full Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
title_fullStr Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
title_full_unstemmed Electrotransfer of plasmid DNA radiosensitizes B16F10 tumors through activation of immune response
title_sort electrotransfer of plasmid dna radiosensitizes b16f10 tumors through activation of immune response
publisher Sciendo
series Radiology and Oncology
issn 1581-3207
publishDate 2017-02-01
description Tumor irradiation combined with adjuvant treatments, either vascular targeted or immunomodulatory, is under intense investigation. Gene electrotransfer of therapeutic genes is one of these approaches. The aim of this study was to determine, whether gene electrotransfer of plasmid encoding shRNA for silencing endoglin, with vascular targeted effectiveness, can radiosensitize melanoma B16F10 tumors.
topic gene therapy
electrotransfer
plasmid
irradiation
immune response
melanoma
url https://doi.org/10.1515/raon-2017-0011
work_keys_str_mv AT savarinmonika electrotransferofplasmiddnaradiosensitizesb16f10tumorsthroughactivationofimmuneresponse
AT kamensekurska electrotransferofplasmiddnaradiosensitizesb16f10tumorsthroughactivationofimmuneresponse
AT cemazarmaja electrotransferofplasmiddnaradiosensitizesb16f10tumorsthroughactivationofimmuneresponse
AT hellerrichard electrotransferofplasmiddnaradiosensitizesb16f10tumorsthroughactivationofimmuneresponse
AT sersagregor electrotransferofplasmiddnaradiosensitizesb16f10tumorsthroughactivationofimmuneresponse
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