Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

Polymeric Pathogen-Like Particles-Based Combination Adjuvants Elicit Potent Mucosal T Cell Immunity to Influenza A Virus

Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like particles (PLPs) loaded with TLR agonists mimic biophysical properties of microbes and hence, simulate pathogen-pattern...

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Bibliographic Details
Main Authors: Brock Kingstad-Bakke, Randall Toy, Woojong Lee, Pallab Pradhan, Gabriela Vogel, Chandranaik B. Marinaik, Autumn Larsen, Daisy Gates, Tracy Luu, Bhawana Pandey, Yoshihoro Kawaoka, Krishnendu Roy, M. Suresh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
adjuvants
CD8
tissue-resident memory
CD4
influenza A virus
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.559382/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.559382/full

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