The challenge of mapping the human connectome based on diffusion tractography

Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.

Bibliographic Details
Main Authors: Klaus H. Maier-Hein, Peter F. Neher, Jean-Christophe Houde, Marc-Alexandre Côté, Eleftherios Garyfallidis, Jidan Zhong, Maxime Chamberland, Fang-Cheng Yeh, Ying-Chia Lin, Qing Ji, Wilburn E. Reddick, John O. Glass, David Qixiang Chen, Yuanjing Feng, Chengfeng Gao, Ye Wu, Jieyan Ma, Renjie He, Qiang Li, Carl-Fredrik Westin, Samuel Deslauriers-Gauthier, J. Omar Ocegueda González, Michael Paquette, Samuel St-Jean, Gabriel Girard, François Rheault, Jasmeen Sidhu, Chantal M. W. Tax, Fenghua Guo, Hamed Y. Mesri, Szabolcs Dávid, Martijn Froeling, Anneriet M. Heemskerk, Alexander Leemans, Arnaud Boré, Basile Pinsard, Christophe Bedetti, Matthieu Desrosiers, Simona Brambati, Julien Doyon, Alessia Sarica, Roberta Vasta, Antonio Cerasa, Aldo Quattrone, Jason Yeatman, Ali R. Khan, Wes Hodges, Simon Alexander, David Romascano, Muhamed Barakovic, Anna Auría, Oscar Esteban, Alia Lemkaddem, Jean-Philippe Thiran, H. Ertan Cetingul, Benjamin L. Odry, Boris Mailhe, Mariappan S. Nadar, Fabrizio Pizzagalli, Gautam Prasad, Julio E. Villalon-Reina, Justin Galvis, Paul M. Thompson, Francisco De Santiago Requejo, Pedro Luque Laguna, Luis Miguel Lacerda, Rachel Barrett, Flavio Dell’Acqua, Marco Catani, Laurent Petit, Emmanuel Caruyer, Alessandro Daducci, Tim B. Dyrby, Tim Holland-Letz, Claus C. Hilgetag, Bram Stieltjes, Maxime Descoteaux
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01285-x
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author Klaus H. Maier-Hein
Peter F. Neher
Jean-Christophe Houde
Marc-Alexandre Côté
Eleftherios Garyfallidis
Jidan Zhong
Maxime Chamberland
Fang-Cheng Yeh
Ying-Chia Lin
Qing Ji
Wilburn E. Reddick
John O. Glass
David Qixiang Chen
Yuanjing Feng
Chengfeng Gao
Ye Wu
Jieyan Ma
Renjie He
Qiang Li
Carl-Fredrik Westin
Samuel Deslauriers-Gauthier
J. Omar Ocegueda González
Michael Paquette
Samuel St-Jean
Gabriel Girard
François Rheault
Jasmeen Sidhu
Chantal M. W. Tax
Fenghua Guo
Hamed Y. Mesri
Szabolcs Dávid
Martijn Froeling
Anneriet M. Heemskerk
Alexander Leemans
Arnaud Boré
Basile Pinsard
Christophe Bedetti
Matthieu Desrosiers
Simona Brambati
Julien Doyon
Alessia Sarica
Roberta Vasta
Antonio Cerasa
Aldo Quattrone
Jason Yeatman
Ali R. Khan
Wes Hodges
Simon Alexander
David Romascano
Muhamed Barakovic
Anna Auría
Oscar Esteban
Alia Lemkaddem
Jean-Philippe Thiran
H. Ertan Cetingul
Benjamin L. Odry
Boris Mailhe
Mariappan S. Nadar
Fabrizio Pizzagalli
Gautam Prasad
Julio E. Villalon-Reina
Justin Galvis
Paul M. Thompson
Francisco De Santiago Requejo
Pedro Luque Laguna
Luis Miguel Lacerda
Rachel Barrett
Flavio Dell’Acqua
Marco Catani
Laurent Petit
Emmanuel Caruyer
Alessandro Daducci
Tim B. Dyrby
Tim Holland-Letz
Claus C. Hilgetag
Bram Stieltjes
Maxime Descoteaux
spellingShingle Klaus H. Maier-Hein
Peter F. Neher
Jean-Christophe Houde
Marc-Alexandre Côté
Eleftherios Garyfallidis
Jidan Zhong
Maxime Chamberland
Fang-Cheng Yeh
Ying-Chia Lin
Qing Ji
Wilburn E. Reddick
John O. Glass
David Qixiang Chen
Yuanjing Feng
Chengfeng Gao
Ye Wu
Jieyan Ma
Renjie He
Qiang Li
Carl-Fredrik Westin
Samuel Deslauriers-Gauthier
J. Omar Ocegueda González
Michael Paquette
Samuel St-Jean
Gabriel Girard
François Rheault
Jasmeen Sidhu
Chantal M. W. Tax
Fenghua Guo
Hamed Y. Mesri
Szabolcs Dávid
Martijn Froeling
Anneriet M. Heemskerk
Alexander Leemans
Arnaud Boré
Basile Pinsard
Christophe Bedetti
Matthieu Desrosiers
Simona Brambati
Julien Doyon
Alessia Sarica
Roberta Vasta
Antonio Cerasa
Aldo Quattrone
Jason Yeatman
Ali R. Khan
Wes Hodges
Simon Alexander
David Romascano
Muhamed Barakovic
Anna Auría
Oscar Esteban
Alia Lemkaddem
Jean-Philippe Thiran
H. Ertan Cetingul
Benjamin L. Odry
Boris Mailhe
Mariappan S. Nadar
Fabrizio Pizzagalli
Gautam Prasad
Julio E. Villalon-Reina
Justin Galvis
Paul M. Thompson
Francisco De Santiago Requejo
Pedro Luque Laguna
Luis Miguel Lacerda
Rachel Barrett
Flavio Dell’Acqua
Marco Catani
Laurent Petit
Emmanuel Caruyer
Alessandro Daducci
Tim B. Dyrby
Tim Holland-Letz
Claus C. Hilgetag
Bram Stieltjes
Maxime Descoteaux
The challenge of mapping the human connectome based on diffusion tractography
Nature Communications
author_facet Klaus H. Maier-Hein
Peter F. Neher
Jean-Christophe Houde
Marc-Alexandre Côté
Eleftherios Garyfallidis
Jidan Zhong
Maxime Chamberland
Fang-Cheng Yeh
Ying-Chia Lin
Qing Ji
Wilburn E. Reddick
John O. Glass
David Qixiang Chen
Yuanjing Feng
Chengfeng Gao
Ye Wu
Jieyan Ma
Renjie He
Qiang Li
Carl-Fredrik Westin
Samuel Deslauriers-Gauthier
J. Omar Ocegueda González
Michael Paquette
Samuel St-Jean
Gabriel Girard
François Rheault
Jasmeen Sidhu
Chantal M. W. Tax
Fenghua Guo
Hamed Y. Mesri
Szabolcs Dávid
Martijn Froeling
Anneriet M. Heemskerk
Alexander Leemans
Arnaud Boré
Basile Pinsard
Christophe Bedetti
Matthieu Desrosiers
Simona Brambati
Julien Doyon
Alessia Sarica
Roberta Vasta
Antonio Cerasa
Aldo Quattrone
Jason Yeatman
Ali R. Khan
Wes Hodges
Simon Alexander
David Romascano
Muhamed Barakovic
Anna Auría
Oscar Esteban
Alia Lemkaddem
Jean-Philippe Thiran
H. Ertan Cetingul
Benjamin L. Odry
Boris Mailhe
Mariappan S. Nadar
Fabrizio Pizzagalli
Gautam Prasad
Julio E. Villalon-Reina
Justin Galvis
Paul M. Thompson
Francisco De Santiago Requejo
Pedro Luque Laguna
Luis Miguel Lacerda
Rachel Barrett
Flavio Dell’Acqua
Marco Catani
Laurent Petit
Emmanuel Caruyer
Alessandro Daducci
Tim B. Dyrby
Tim Holland-Letz
Claus C. Hilgetag
Bram Stieltjes
Maxime Descoteaux
author_sort Klaus H. Maier-Hein
title The challenge of mapping the human connectome based on diffusion tractography
title_short The challenge of mapping the human connectome based on diffusion tractography
title_full The challenge of mapping the human connectome based on diffusion tractography
title_fullStr The challenge of mapping the human connectome based on diffusion tractography
title_full_unstemmed The challenge of mapping the human connectome based on diffusion tractography
title_sort challenge of mapping the human connectome based on diffusion tractography
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Though tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.
url https://doi.org/10.1038/s41467-017-01285-x
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spelling doaj-67c5930443f649148e606525891370e82021-05-11T07:25:00ZengNature Publishing GroupNature Communications2041-17232017-11-018111310.1038/s41467-017-01285-xThe challenge of mapping the human connectome based on diffusion tractographyKlaus H. Maier-Hein0Peter F. Neher1Jean-Christophe Houde2Marc-Alexandre Côté3Eleftherios Garyfallidis4Jidan Zhong5Maxime Chamberland6Fang-Cheng Yeh7Ying-Chia Lin8Qing Ji9Wilburn E. Reddick10John O. Glass11David Qixiang Chen12Yuanjing Feng13Chengfeng Gao14Ye Wu15Jieyan Ma16Renjie He17Qiang Li18Carl-Fredrik Westin19Samuel Deslauriers-Gauthier20J. Omar Ocegueda González21Michael Paquette22Samuel St-Jean23Gabriel Girard24François Rheault25Jasmeen Sidhu26Chantal M. W. Tax27Fenghua Guo28Hamed Y. Mesri29Szabolcs Dávid30Martijn Froeling31Anneriet M. Heemskerk32Alexander Leemans33Arnaud Boré34Basile Pinsard35Christophe Bedetti36Matthieu Desrosiers37Simona Brambati38Julien Doyon39Alessia Sarica40Roberta Vasta41Antonio Cerasa42Aldo Quattrone43Jason Yeatman44Ali R. Khan45Wes Hodges46Simon Alexander47David Romascano48Muhamed Barakovic49Anna Auría50Oscar Esteban51Alia Lemkaddem52Jean-Philippe Thiran53H. Ertan Cetingul54Benjamin L. Odry55Boris Mailhe56Mariappan S. Nadar57Fabrizio Pizzagalli58Gautam Prasad59Julio E. Villalon-Reina60Justin Galvis61Paul M. Thompson62Francisco De Santiago Requejo63Pedro Luque Laguna64Luis Miguel Lacerda65Rachel Barrett66Flavio Dell’Acqua67Marco Catani68Laurent Petit69Emmanuel Caruyer70Alessandro Daducci71Tim B. Dyrby72Tim Holland-Letz73Claus C. Hilgetag74Bram Stieltjes75Maxime Descoteaux76Division of Medical Image Computing, German Cancer Research Center (DKFZ)Division of Medical Image Computing, German Cancer Research Center (DKFZ)Sherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeKrembil Research Institute, University Health NetworkSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeDepartment of Neurological Surgery, University of Pittsburgh School of MedicineIMT—Institute for Advanced StudiesDepartment of Diagnostic Imaging, St. Jude Children’s Research HospitalDepartment of Diagnostic Imaging, St. Jude Children’s Research HospitalDepartment of Diagnostic Imaging, St. Jude Children’s Research HospitalUniversity of Toronto Institute of Medical ScienceInstitute of Information Processing and Automation, Zhejiang University of TechnologyInstitute of Information Processing and Automation, Zhejiang University of TechnologyInstitute of Information Processing and Automation, Zhejiang University of TechnologyUnited Imaging Healthcare Co.United Imaging Healthcare Co.United Imaging Healthcare Co.Laboratory of Mathematics in Imaging, Harvard Medical SchoolSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeCenter for Research in MathematicsSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookePROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtPROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtPROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtPROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtDepartment of Radiology, University Medical Center UtrechtPROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtPROVIDI Lab, Image Sciences Institute, University Medical Center UtrechtCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalCentre de recherche institut universitaire de geriatrie de Montreal (CRIUGM), Université de MontréalNeuroimaging Unit, Institute of Bioimaging and Molecular Physiology (IBFM), National Research Council (CNR), Policlinico Magna GraeciaNeuroimaging Unit, Institute of Bioimaging and Molecular Physiology (IBFM), National Research Council (CNR), Policlinico Magna GraeciaNeuroimaging Unit, Institute of Bioimaging and Molecular Physiology (IBFM), National Research Council (CNR), Policlinico Magna GraeciaNeuroimaging Unit, Institute of Bioimaging and Molecular Physiology (IBFM), National Research Council (CNR), Policlinico Magna GraeciaInstitute for Learning & Brain Sciences and Department of Speech & Hearing Sciences, University of WashingtonDepartments of Medical Biophysics & Medical Imaging, Schulich School of Medicine and Dentistry, Western UniversitySynaptive Medical Inc.Synaptive Medical Inc.Signal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneSignal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneSignal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneBiomedical Image Technologies (BIT), ETSI Telecom., U. Politécnica de Madrid and CIBER-BBNSignal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneSignal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneMedical Imaging Technologies, Siemens HealthcareMedical Imaging Technologies, Siemens HealthcareMedical Imaging Technologies, Siemens HealthcareMedical Imaging Technologies, Siemens HealthcareImaging Genetics Center, Stevens Neuro Imaging and Informatics Institute, Keck School of Medicine of USCImaging Genetics Center, Stevens Neuro Imaging and Informatics Institute, Keck School of Medicine of USCImaging Genetics Center, Stevens Neuro Imaging and Informatics Institute, Keck School of Medicine of USCImaging Genetics Center, Stevens Neuro Imaging and Informatics Institute, Keck School of Medicine of USCImaging Genetics Center, Stevens Neuro Imaging and Informatics Institute, Keck School of Medicine of USCNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonNatBrainLab, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonGroupe d’imagerie Neurofonctionnelle—Institut des Maladies Neurodégénératives (GIN-IMN), UMR5293 CNRS, CEA, University of BordeauxCentre national de la recherche scientifique (CNRS), Institute for Research in IT and Random Systems (IRISA)Signal Processing Lab (LTS5), Ecole Polytechnique Federale de LausanneDanish Research Centre for Magnetic Resonance, Center for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital HvidovreDivision of Biostatistics, German Cancer Research Center (DKFZ)Department of Computational Neuroscience, University Medical Center EppendorfUniversity Hospital Basel, Radiology & Nuclear Medicine ClinicSherbrooke Connectivity Imaging Lab (SCIL), Université de SherbrookeThough tractography is widely used, it has not been systematically validated. Here, authors report results from 20 groups showing that many tractography algorithms produce both valid and invalid bundles.https://doi.org/10.1038/s41467-017-01285-x