Transport and biotransformation of the new cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate (Bamet-R2) by the rat liver1

Transport and biotransformation of the new cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate (Bamet-R2) by the rat liver1

Rat liver uptake and bile output of the cytostatic complex cis-diammineplatinum(II)-chlorocholylglycinate (Bamet-R2) were studied. Up to 100 μm, Bamet-R2 uptake by rat hepatocytes in primary culture followed saturation kinetics (Vmax = 0.65 ± 0.12 nmol/5 min per mg protein; KM = 45.2 ± 10.7 μm). Bam...

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Bibliographic Details
Main Authors: Rocio I.R. Macias, Maria J. Monte, Mohamed Y. El-Mir, Gloria R. Villanueva, Jose J.G. Marin
Format: Article
Language:English
Published: Elsevier 1998-09-01
Series:Journal of Lipid Research
Subjects:
bile acid
cancer
chemotherapy
cisplatin
glycocholate
metal
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520321660

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http://www.sciencedirect.com/science/article/pii/S0022227520321660

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